General Structure Information
| PDB ID | 2vqv |
| HGNC Gene Label(s) | HDAC4 |
| Structure Name | structure of hdac4 catalytic domain with a gain-of-function mutation bound to a hydroxamic acid inhibitor |
| Resolution | 3.3Å |
| Reference | AUTH M.J.BOTTOMLEY,P.LO SURDO,P.DI GIOVINE,A.CIRILLO,AUTH 2 R.SCARPELLI,F.FERRIGNO,P.JONES,P.NEDDERMANN,AUTH 3 R.DE FRANCESCO,C.STEINKUHLER,P.GALLINARI,A.CARFITITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE HUMANTITL 2 HDAC4 CATALYTIC DOMAIN REVEALS A REGULATORYTITL 3 STRUCTURAL ZINC-BINDING DOMAIN.REF J.BIOL.CHEM. V. 283 26694 2008REFN ISSN 0021-9258PMID 18614528DOI 10.1074/JBC.M803514200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 355 |
| Number Of SNVs | 81 |
| Number Of Permutations | 15110 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.107 |
| p-value | 0.601 |
COSMIC
| Number Of Residues | 355 |
| Number Of SNVs | 4 |
| Number Of Permutations | 120 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.167 |
| p-value | 0.811 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 81 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.321 |
| p-value | 0.738 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
