General Structure Information
| PDB ID | 4lcj |
| HGNC Gene Label(s) | CTBP2 |
| Structure Name | ctbp2 in complex with substrate mtob |
| Resolution | 2.86Å |
| Reference | AUTH B.J.HILBERT,S.R.GROSSMANN,C.A.SCHIFFER,W.E.ROYERTITL CRYSTAL STRUCTURES OF HUMAN CTBP IN COMPLEX WITH SUBSTRATETITL 2 MTOB REVEAL ACTIVE SITE FEATURES USEFUL FOR INHIBITORTITL 3 DESIGN.REF FEBS LETT. V. 588 1743 2014REFN ISSN 0014-5793PMID 24657618DOI 10.1016/J.FEBSLET.2014.03.026 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 329 |
| Number Of SNVs | 61 |
| Number Of Permutations | 39095 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.138 |
| p-value | 0.433 |
COSMIC
| Number Of Residues | 329 |
| Number Of SNVs | 16 |
| Number Of Permutations | 16092 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.158 |
| p-value | 0.583 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 61 |
| Number Of COSMIC SNVs | 12 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | 0.177 |
| p-value | 0.178 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
