2M2F.A | ADAM17

General Structure Information

PDB ID 2m2f
HGNC Gene Label(s) ADAM17
Structure Name the membran-proximal domain of adam17
Resolution -1.0Å
Reference AUTH S.DUSTERHOFT,S.JUNG,C.W.HUNG,A.THOLEY,F.D.SONNICHSEN,AUTH 2 J.GROTZINGER,I.LORENZENTITL MEMBRANE-PROXIMAL DOMAIN OF A DISINTEGRIN ANDTITL 2 METALLOPROTEASE-17 REPRESENTS THE PUTATIVE MOLECULAR SWITCHTITL 3 OF ITS SHEDDING ACTIVITY OPERATED BY PROTEIN-DISULFIDETITL 4 ISOMERASE.REF J.AM.CHEM.SOC. V. 135 5776 2013REFN ISSN 0002-7863PMID 23521534DOI 10.1021/JA400340U

Variant Set Distributions

ExAC Variants

Number Of Residues 62
Number Of SNVs 11
Number Of Permutations 594
Optimal Distance Threshold 10.0
K Statistic 0.127
p-value 0.049

Mapped Variants

[+] ExAC Missense Variants