General Structure Information
| PDB ID | 3hu2 |
| HGNC Gene Label(s) | VCP |
| Structure Name | structure of p97 n-d1 r86a mutant in complex with atpgs |
| Resolution | 2.85Å |
| Reference | AUTH W.K.TANG,D.LI,C.C.LI,L.ESSER,R.DAI,L.GUO,D.XIATITL A NOVEL ATP-DEPENDENT CONFORMATION IN P97 N-D1 FRAGMENTTITL 2 REVEALED BY CRYSTAL STRUCTURES OF DISEASE-RELATED MUTANTS.REF EMBO J. V. 29 2217 2010REFN ISSN 0261-4189PMID 20512113DOI 10.1038/EMBOJ.2010.104 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 452 |
| Number Of SNVs | 35 |
| Number Of Permutations | 6538 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.175 |
| p-value | 0.734 |
ClinVar
| Number Of Residues | 452 |
| Number Of SNVs | 7 |
| Number Of Permutations | 1194 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.095 |
| p-value | 0.292 |
COSMIC
| Number Of Residues | 452 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1144 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.1 |
| p-value | 0.687 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 35 |
| Number Of ClinVar SNVs | 7 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.07 |
| p-value | 0.36 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 35 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.165 |
| p-value | 0.252 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
