General Structure Information
| PDB ID | 2lxp |
| HGNC Gene Label(s) | UBE2G2 |
| Structure Name | nmr structure of two domains in ubiquitin ligase gp78, ring and g2br, bound to its conjugating enzyme ube2g |
| Resolution | -1.0Å |
| Reference | AUTH R.DAS,Y.H.LIANG,J.MARIANO,J.LI,T.HUANG,A.KING,S.G.TARASOV,AUTH 2 A.M.WEISSMAN,X.JI,R.A.BYRDTITL ALLOSTERIC REGULATION OF E2:E3 INTERACTIONS PROMOTE ATITL 2 PROCESSIVE UBIQUITINATION MACHINE.REF EMBO J. V. 32 2504 2013REFN ISSN 0261-4189PMID 23942235DOI 10.1038/EMBOJ.2013.174 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 156 |
| Number Of SNVs | 25 |
| Number Of Permutations | 3184 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.05 |
| p-value | 0.287 |
COSMIC
| Number Of Residues | 156 |
| Number Of SNVs | 4 |
| Number Of Permutations | 186 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.167 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 25 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.25 |
| p-value | 0.901 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
