General Structure Information
| PDB ID | 2xzg |
| HGNC Gene Label(s) | CLTC |
| Structure Name | clathrin terminal domain complexed with pitstop 1 |
| Resolution | 1.7Å |
| Reference | AUTH L.VON KLEIST,W.STAHLSCHMIDT,H.BULUT,K.GROMOVA,D.PUCHKOV,AUTH 2 M.J.ROBERTSON,K.A.MACGREGOR,N.TOMLIN,A.PECHSTEIN,N.CHAU,AUTH 3 M.CHIRCOP,J.SAKOFF,J.P.VON KRIES,W.SAENGER,H.KRAUSSLICH,AUTH 4 O.SHUPLIAKOV,P.J.ROBINSON,A.MCCLUSKEY,V.HAUCKETITL ROLE OF THE CLATHRIN TERMINAL DOMAIN IN REGULATING COATEDTITL 2 PIT DYNAMICS REVEALED BY SMALL MOLECULE INHIBITION.REF CELL(CAMBRIDGE,MASS.) V. 146 471 2011REFN ISSN 0092-8674PMID 21816279DOI 10.1016/J.CELL.2011.06.025 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 357 |
| Number Of SNVs | 31 |
| Number Of Permutations | 4771 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.03 |
| p-value | 0.408 |
COSMIC
| Number Of Residues | 357 |
| Number Of SNVs | 4 |
| Number Of Permutations | 218 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.167 |
| p-value | 0.588 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 31 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.128 |
| p-value | 0.797 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
