General Structure Information
| PDB ID | 3nkx |
| HGNC Gene Label(s) | YWHAZ |
| Structure Name | impaired binding of 14-3-3 to raf1 is linked to noonan and leopard syndrome |
| Resolution | 2.4Å |
| Reference | AUTH M.MOLZAN,B.SCHUMACHER,C.OTTMANN,A.BALJULS,L.POLZIEN,AUTH 2 M.WEYAND,P.THIEL,R.ROSE,M.ROSE,P.KUHENNE,M.KAISER,U.R.RAPP,AUTH 3 J.KUHLMANN,C.OTTMANNTITL IMPAIRED BINDING OF 14-3-3 TO C-RAF IN NOONAN SYNDROMETITL 2 SUGGESTS NEW APPROACHES IN DISEASES WITH INCREASED RASTITL 3 SIGNALINGREF MOL.CELL.BIOL. V. 30 4698 2010REFN ISSN 0270-7306PMID 20679480DOI 10.1128/MCB.01636-09 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 229 |
| Number Of SNVs | 12 |
| Number Of Permutations | 6381 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.076 |
| p-value | 0.829 |