General Structure Information
| PDB ID | 1l8l |
| HGNC Gene Label(s) | PSPH |
| Structure Name | molecular basis for the local confomational rearrangement of human phosphoserine phosphatase |
| Resolution | 2.51Å |
| Reference | AUTH H.Y.KIM,Y.S.HEO,J.H.KIM,M.H.PARK,J.MOON,E.KIM,AUTH 2 D.KWON,J.YOON,D.SHIN,E.J.JEONG,S.Y.PARK,T.G.LEE,AUTH 3 Y.H.JEON,S.RO,J.M.CHO,K.Y.HWANGTITL MOLECULAR BASIS FOR THE LOCAL CONFORMATIONALTITL 2 REARRANGEMENT OF HUMAN PHOSPHOSERINE PHOSPHATASE.REF J.BIOL.CHEM. V. 277 46651 2002REFN ISSN 0021-9258PMID 12213811DOI 10.1074/JBC.M204866200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 222 |
| Number Of SNVs | 57 |
| Number Of Permutations | 9267 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.014 |
| p-value | 0.246 |
ClinVar
| Number Of Residues | 222 |
| Number Of SNVs | 3 |
| Number Of Permutations | 150 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.333 |
| p-value | 0.125 |
COSMIC
| Number Of Residues | 222 |
| Number Of SNVs | 10 |
| Number Of Permutations | 5010 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.4 |
| p-value | 0.478 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 57 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.32 |
| p-value | 0.078 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 57 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | -0.093 |
| p-value | 0.743 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
