General Structure Information
| PDB ID | 4kfm |
| HGNC Gene Label(s) | GNB1 |
| Structure Name | crystal structure of the g protein-gated inward rectifier k+ channel girk2 (kir3.2) in complex with the beta-gamma g protein subunits |
| Resolution | 3.45Å |
| Reference | AUTH M.R.WHORTON,R.MACKINNONTITL X-RAY STRUCTURE OF THE MAMMALIAN GIRK2-BETA GAMMA G-PROTEINTITL 2 COMPLEX.REF NATURE V. 498 190 2013REFN ISSN 0028-0836PMID 23739333DOI 10.1038/NATURE12241 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 339 |
| Number Of SNVs | 22 |
| Number Of Permutations | 4858 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.039 |
| p-value | 0.429 |
COSMIC
| Number Of Residues | 339 |
| Number Of SNVs | 4 |
| Number Of Permutations | 41 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.167 |
| p-value | 0.004 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 22 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.167 |
| p-value | 0.006 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
