General Structure Information
| PDB ID | 1vjb |
| HGNC Gene Label(s) | ESRRG |
| Structure Name | crystal structure of the ligand-binding domain of the estrogen-related receptor gamma in complex with 4- hydroxytamoxifen |
| Resolution | 3.2Å |
| Reference | AUTH H.GRESCHIK,R.FLAIG,J.P.RENAUD,D.MORASTITL STRUCTURAL BASIS FOR THE DEACTIVATION OF THETITL 2 ESTROGEN-RELATED RECEPTOR {GAMMA} BYTITL 3 DIETHYLSTILBESTROL OR 4-HYDROXYTAMOXIFEN ANDTITL 4 DETERMINANTS OF SELECTIVITY.REF J.BIOL.CHEM. V. 279 33639 2004REFN ISSN 0021-9258PMID 15161930DOI 10.1074/JBC.M402195200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 210 |
| Number Of SNVs | 32 |
| Number Of Permutations | 13574 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.022 |
| p-value | 0.363 |
COSMIC
| Number Of Residues | 210 |
| Number Of SNVs | 4 |
| Number Of Permutations | 88 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.167 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 32 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.444 |
| p-value | 0.754 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
