General Structure Information
| PDB ID | 2wng |
| HGNC Gene Label(s) | SIRPA |
| Structure Name | complete extracellular structure of human signal regulatory protein (sirp) alpha |
| Resolution | 2.49Å |
| Reference | AUTH D.HATHERLEY,S.C.GRAHAM,K.HARLOS,D.I.STUART,AUTH 2 A.N.BARCLAYTITL STRUCTURE OF SIGNAL-REGULATORY PROTEIN ALPHA: ATITL 2 LINK TO ANTIGEN RECEPTOR EVOLUTION.REF J.BIOL.CHEM. V. 284 26613 2009REFN ISSN 0021-9258PMID 19628875DOI 10.1074/JBC.M109.017566 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 307 |
| Number Of SNVs | 43 |
| Number Of Permutations | 46293 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.029 |
| p-value | 0.632 |
COSMIC
| Number Of Residues | 307 |
| Number Of SNVs | 14 |
| Number Of Permutations | 15736 |
| Optimal Distance Threshold | 34.0 |
| K Statistic | 0.791 |
| p-value | 0.002 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 43 |
| Number Of COSMIC SNVs | 13 |
| Optimal Distance Threshold | 33.0 |
| K Statistic | 0.317 |
| p-value | 0.027 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
