General Structure Information
| PDB ID | 1zy7 |
| HGNC Gene Label(s) | ADARB1 |
| Structure Name | crystal structure of the catalytic domain of an adenosine deaminase that acts on rna (hadar2) bound to inositol hexakisphosphate (ihp) |
| Resolution | 1.7Å |
| Reference | AUTH M.R.MACBETH,H.L.SCHUBERT,A.P.VANDEMARK,A.T.LINGAM,AUTH 2 C.P.HILL,B.L.BASSTITL INOSITOL HEXAKISPHOSPHATE IS BOUND IN THE ADAR2TITL 2 CORE AND REQUIRED FOR RNA EDITING.REF SCIENCE V. 309 1534 2005REFN ISSN 0036-8075PMID 16141067DOI 10.1126/SCIENCE.1113150 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 378 |
| Number Of SNVs | 55 |
| Number Of Permutations | 6160 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.182 |
| p-value | 0.021 |
COSMIC
| Number Of Residues | 378 |
| Number Of SNVs | 7 |
| Number Of Permutations | 667 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.048 |
| p-value | 0.254 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 55 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | -0.123 |
| p-value | 0.509 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
