General Structure Information
| PDB ID | 4md7 |
| HGNC Gene Label(s) | CSNK2B |
| Structure Name | crystal structure of full-length symmetric ck2 holoenzyme |
| Resolution | 3.1Å |
| Reference | AUTH G.LOLLI,A.RANCHIO,R.BATTISTUTTATITL ACTIVE FORM OF THE PROTEIN KINASE CK2 ALPHA 2 BETA 2TITL 2 HOLOENZYME IS A STRONG COMPLEX WITH SYMMETRIC ARCHITECTURE.REF ACS CHEM.BIOL. V. 9 366 2014REFN ISSN 1554-8929PMID 24175891DOI 10.1021/CB400771Y |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 195 |
| Number Of SNVs | 13 |
| Number Of Permutations | 3769 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.526 |
| p-value | 0.409 |
COSMIC
| Number Of Residues | 195 |
| Number Of SNVs | 3 |
| Number Of Permutations | 109 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.667 |
| p-value | 0.255 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 13 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.474 |
| p-value | 0.577 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
