General Structure Information
| PDB ID | 4h3b |
| HGNC Gene Label(s) | MAPK10 |
| Structure Name | crystal structure of jnk3 in complex with sab peptide |
| Resolution | 2.08Å |
| Reference | AUTH J.D.LAUGHLIN,J.C.NWACHUKWU,M.FIGUERA-LOSADA,L.CHERRY,AUTH 2 K.W.NETTLES,P.V.LOGRASSOTITL STRUCTURAL MECHANISMS OF ALLOSTERY AND AUTOINHIBITION IN JNKTITL 2 FAMILY KINASES.REF STRUCTURE V. 20 2174 2012REFN ISSN 0969-2126PMID 23142346DOI 10.1016/J.STR.2012.09.021 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 351 |
| Number Of SNVs | 36 |
| Number Of Permutations | 21209 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.319 |
| p-value | 0.608 |
COSMIC
| Number Of Residues | 351 |
| Number Of SNVs | 6 |
| Number Of Permutations | 820 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.133 |
| p-value | 0.067 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 36 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | -0.217 |
| p-value | 0.178 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
