General Structure Information
| PDB ID | 2ayn |
| HGNC Gene Label(s) | USP14 |
| Structure Name | structure of usp14, a proteasome-associated deubiquitinating enzyme |
| Resolution | 3.2Å |
| Reference | AUTH M.HU,P.LI,L.SONG,P.D.JEFFREY,T.A.CHENOVA,AUTH 2 K.D.WILKINSON,R.E.COHEN,Y.SHITITL STRUCTURE AND MECHANISMS OF THETITL 2 PROTEASOME-ASSOCIATED DEUBIQUITINATING ENZYMETITL 3 USP14.REF EMBO J. V. 24 3747 2005REFN ISSN 0261-4189PMID 16211010DOI 10.1038/SJ.EMBOJ.7600832 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 337 |
| Number Of SNVs | 52 |
| Number Of Permutations | 29711 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.009 |
| p-value | 0.863 |
COSMIC
| Number Of Residues | 337 |
| Number Of SNVs | 3 |
| Number Of Permutations | 168 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.667 |
| p-value | 0.289 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 52 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.516 |
| p-value | 0.325 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
