3HFW.A | ADPRH

General Structure Information

PDB ID	3hfw
HGNC Gene Label(s)	ADPRH
Structure Name	crystal structure of human adp-ribosylhydrolase 1 (harh1)
Resolution	1.92Å
Reference	AUTH F.KOCH-NOLTE,J.MUELLER-DIECKMANN,M.S.WEISS,AUTH 2 C.MUELLER-DIECKMANNTITL CRYSTAL STRUCTURE OF HUMAN ADP-RIBOSYLHYDROLASE 1REF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	357
Number Of SNVs	102
Number Of Permutations	13557
Optimal Distance Threshold	16.0
K Statistic	0.251
p-value	0.004

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
3:119301032	rs370199855	A>T	A:6	(38.39, 3.52, 20.86)
3:119301040		M>I	A:8	(37.39, 6.43, 15.66)
3:119301054		A>G	A:13	(30.80, -0.43, 16.39)
3:119301056		G>R	A:14	(27.86, 1.11, 17.00)
3:119301061		D>E	A:15	(27.10, 2.50, 13.12)
3:119301068		G>R	A:18	(22.50, -0.56, 15.23)
3:119301072	rs147901245	Y>C	A:19	(22.55, -0.31, 9.63)
3:119301078		N>S	A:21	(23.11, -4.68, 7.62)
3:119301085		K>N	A:23	(17.02, -6.15, 10.85)
3:119301095		L>V	A:27	(13.05, -2.23, 14.00)
3:119301113	rs201822828	I>V	A:33	(15.83, -4.69, 18.70)
3:119301118	rs368027725	H>Q	A:34	(16.60, -5.35, 23.38)
3:119301119		R>W	A:35	(12.09, -9.81, 21.45)
3:119301120		R>Q	A:35	(12.09, -9.81, 21.45)
3:119301135		L>P	A:40	(21.91, -13.13, 17.97)
3:119301140		G>S	A:42	(24.14, -11.20, 22.78)
3:119301144	rs547308034	L>S	A:43	(26.59, -7.32, 22.94)
3:119301148		D>E	A:44	(29.34, -10.28, 24.66)
3:119301153		L>Q	A:46	(27.16, -9.64, 18.51)
3:119301158	rs146978056	V>M	A:48	(30.97, -6.89, 13.45)
3:119301161		G>R	A:49	(32.02, -8.84, 9.99)
3:119301182	COSM3391973 COSM1582549	D>N	A:56	(26.85, 7.47, 10.60)
3:119301185	rs145782367	T>A	A:57	(31.36, 5.52, 9.98)
3:119301201		A>V	A:62	(35.68, 12.12, 6.33)
3:119301206	rs138015780	A>T	A:64	(39.06, 12.56, 10.23)
3:119301209		E>Q	A:65	(40.46, 10.82, 6.54)
3:119301225	rs201028402	A>G	A:70	(45.30, 19.68, 7.52)
3:119301244		L>F	A:76	(40.10, 27.19, 8.73)
3:119301255	rs149117576	Y>C	A:80	(36.47, 24.82, 6.44)
3:119301258	rs192856664	Y>C	A:81	(39.61, 21.49, -0.72)
3:119301267		A>G	A:84	(34.25, 19.24, 1.11)
3:119301269		K>E	A:85	(37.08, 16.62, -1.97)
3:119301275		Y>D	A:87	(31.99, 15.78, 4.32)
3:119301288		M>T	A:91	(28.36, 10.37, -0.68)
3:119301295		D>E	A:93	(31.13, 4.28, 0.48)
3:119301302	rs200634555 TMP_ESP_3_119301302_119301302	G>R	A:96	(23.62, 0.03, 2.08)
3:119301305	COSM1418029	R>G	A:97	(26.83, 2.14, 3.95)
3:119301306		R>Q	A:97	(26.83, 2.14, 3.95)
3:119305141	rs367735796	S>L	A:103	(23.84, 14.34, 3.91)
3:119305147		H>P	A:105	(21.15, 17.35, -2.00)
3:119305155		M>L	A:108	(26.45, 15.07, -4.15)
3:119305165		K>R	A:111	(31.11, 23.15, -5.98)
3:119305179	rs368454824	N>Y	A:116	(32.82, 30.48, 0.23)
3:119305212		G>C	A:127	(17.94, 19.10, 11.35)
3:119305215		G>S	A:128	(19.51, 16.63, 11.20)
3:119305216	rs369779554	G>V	A:128	(19.51, 16.63, 11.20)
3:119305222	COSM3974108	G>V	A:130	(24.46, 14.37, 10.07)
3:119305230		M>V	A:133	(26.84, 11.53, 12.05)
3:119305233	rs137924029	R>W	A:134	(29.45, 14.83, 9.92)
3:119305234	rs142179039	R>Q	A:134	(29.45, 14.83, 9.92)
3:119305242		C>R	A:137	(36.79, 14.02, 15.42)
3:119305267		H>R	A:145	(40.20, 26.39, 27.22)
3:119305294		V>A	A:154	(35.29, 23.42, 12.65)
3:119305304		E>D	A:157	(31.11, 26.06, 9.04)
3:119305305		S>C	A:158	(31.11, 20.83, 9.42)
3:119305309	rs575459268	G>D	A:159	(27.62, 21.05, 9.27)
3:119305312	rs189558030	R>Q	A:160	(26.90, 26.34, 8.10)
3:119305320		H>Y	A:163	(22.80, 19.55, 8.08)
3:119305323		H>D	A:164	(22.53, 26.59, 7.09)
3:119305326		H>Y	A:165	(18.47, 24.47, 11.19)
3:119305332	rs139344767	T>A	A:167	(18.81, 21.86, 15.09)
3:119305333		T>I	A:167	(18.81, 21.86, 15.09)
3:119305347		A>P	A:172	(28.16, 19.22, 15.80)
3:119305354	rs201509638	A>V	A:174	(27.83, 18.58, 20.87)
3:119305375		Y>S	A:181	(33.81, 18.73, 27.64)
3:119305377		A>T	A:182	(36.35, 13.13, 27.32)
3:119305405		W>S	A:191	(30.07, 15.83, 29.12)
3:119305419		M>L	A:196	(23.89, 25.17, 27.52)
3:119305421		M>I	A:196	(23.89, 25.17, 27.52)
3:119305456		Q>P	A:208	(31.19, 36.70, 12.56)
3:119305479		N>D	A:216	(20.36, 30.95, 11.70)
3:119306313		S>C	A:221	(14.96, 28.31, 20.41)
3:119306319	rs558829713	F>Y	A:223	(19.93, 22.71, 20.37)
3:119306324		T>A	A:225	(14.39, 24.79, 24.68)
3:119306357		I>V	A:236	(22.07, 17.74, 34.79)
3:119306358		I>S	A:236	(22.07, 17.74, 34.79)
3:119306366		G>R	A:239	(26.78, 20.41, 36.72)
3:119306385		F>S	A:245	(18.07, 8.39, 35.16)
3:119306397	rs537852686	F>S	A:249	(14.25, 4.60, 31.60)
3:119306399		G>S	A:250	(12.93, 0.57, 30.07)
3:119306433		L>P	A:261	(13.50, 13.81, 23.04)
3:119306441	rs147911198	S>P	A:264	(9.06, 14.09, 13.69)
3:119306447	rs139662260	W>G	A:266	(13.82, 8.16, 13.18)
3:119306466		H>R	A:272	(17.61, 17.61, 19.13)
3:119306468	rs145418642	D>N	A:273	(17.70, 13.91, 19.23)
3:119306482	rs199863749	I>M	A:277	(19.68, 9.74, 23.08)
3:119306483		A>T	A:278	(24.11, 9.51, 23.78)
3:119306484		A>V	A:278	(24.11, 9.51, 23.78)
3:119306489	rs367917789	D>N	A:280	(20.69, 9.67, 28.80)
3:119306495		V>I	A:282	(27.11, 8.14, 28.87)
3:119306498		L>I	A:283	(24.84, 10.09, 32.13)
3:119306505		A>G	A:285	(26.64, 3.40, 31.81)
3:119306514		S>F	A:288	(28.77, -0.51, 30.87)
3:119306532		H>P	A:294	(21.43, -2.71, 26.39)
3:119306535	rs150984649	R>Q	A:295	(20.08, 2.80, 28.33)
3:119306568		T>I	A:306	(22.48, 7.25, 18.90)
3:119306573		A>T	A:308	(28.15, 6.72, 16.82)
3:119306579	rs200018595	A>T	A:310	(28.14, 6.97, 22.25)
3:119306582		G>S	A:311	(31.08, 5.34, 21.30)
3:119306586		C>Y	A:312	(33.25, 8.17, 20.58)
3:119306603		Y>H	A:318	(35.38, 4.13, 30.18)
3:119306625	rs375932383	P>L	A:325	(36.56, -9.03, 21.12)
3:119306633		Y>H	A:328	(36.89, -4.84, 18.53)
3:119306634		Y>C	A:328	(36.89, -4.84, 18.53)
3:119306645		E>K	A:332	(33.61, -1.91, 7.27)
3:119306648		Y>H	A:333	(36.19, 0.93, 6.25)
3:119306655		N>S	A:335	(43.47, -0.56, 9.50)
3:119306657		R>W	A:336	(39.92, 4.07, 6.69)
3:119306658	rs528878906	R>Q	A:336	(39.92, 4.07, 6.69)
3:119306661		L>R	A:337	(38.98, 3.58, 12.06)
3:119306678	rs367626621	A>P	A:343	(46.91, 10.90, 13.57)
3:119306700		K>R	A:350	(51.32, 19.28, 20.77)