General Structure Information
| PDB ID | 4jg7 |
| HGNC Gene Label(s) | RPS6KA3 |
| Structure Name | structure of rsk2 ctd bound to 3-(3-(1h-pyrrolo[2,3-b]pyridine-3- carbonyl)phenyl)-2-cyanoacrylamide |
| Resolution | 3.0Å |
| Reference | AUTH R.M.MILLER,V.O.PAAVILAINEN,S.KRISHNAN,I.M.SERAFIMOVA,AUTH 2 J.TAUNTONTITL ELECTROPHILIC FRAGMENT-BASED DESIGN OF REVERSIBLE COVALENTTITL 2 KINASE INHIBITORS.REF J.AM.CHEM.SOC. V. 135 5298 2013REFN ISSN 0002-7863PMID 23540679DOI 10.1021/JA401221B |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 307 |
| Number Of SNVs | 12 |
| Number Of Permutations | 1861 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.03 |
| p-value | 0.847 |
COSMIC
| Number Of Residues | 307 |
| Number Of SNVs | 9 |
| Number Of Permutations | 2122 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.111 |
| p-value | 0.635 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 12 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | -0.104 |
| p-value | 0.168 |