General Structure Information
| PDB ID | 2cjz |
| HGNC Gene Label(s) | PTPN5 |
| Structure Name | crystal structure of the c472s mutant of human protein tyrosine phosphatase ptpn5 (step, striatum enriched phosphatase) in complex with phosphotyrosine |
| Resolution | 1.7Å |
| Reference | AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.F.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 268 |
| Number Of SNVs | 69 |
| Number Of Permutations | 25310 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.093 |
| p-value | 0.121 |
COSMIC
| Number Of Residues | 268 |
| Number Of SNVs | 5 |
| Number Of Permutations | 357 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.1 |
| p-value | 0.797 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 69 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.291 |
| p-value | 0.155 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
