2CKJ.A | XDH – ASTRID

2CKJ.A | XDH

General Structure Information

PDB ID	2ckj
HGNC Gene Label(s)	XDH
Structure Name	human milk xanthine oxidoreductase
Resolution	3.59Å
Reference	AUTH A.R.PEARSON,B.L.J.GODBER,R.EISENTHAL,G.L.TAYLOR,AUTH 2 R.HARRISONTITL HUMAN MILK XANTHINE DEHYDROGENASE IS INCOMPLETELYTITL 2 CONVERTED TO THE OXIDASE FORM IN THE ABSENCE OFTITL 3 PROTEOLYSIS. A STRUCTURAL EXPLANATION.REF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	1264
Number Of SNVs	398
Number Of Permutations	94182
Optimal Distance Threshold	7.0
K Statistic	0.006
p-value	0.743

COSMIC

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	398
Number Of COSMIC SNVs	27
Optimal Distance Threshold	8.0
K Statistic	0.009
p-value	0.278

Pathogenic Proximity Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:31637526	rs144150776	A>T	A:3	(90.49, 131.86, 133.46)
2:31637513		V>G	A:7	(84.54, 124.46, 127.31)
2:31637500	rs201779309	N>K	A:11	(77.82, 112.82, 122.97)
2:31628817		N>S	A:19	(82.57, 127.00, 139.05)
2:31628791		A>T	A:28	(81.14, 111.74, 137.47)
2:31628787		Y>C	A:29	(80.35, 116.51, 134.66)
2:31628788		Y>H	A:29	(80.35, 116.51, 134.66)
2:31628778		R>I	A:32	(77.67, 111.50, 140.00)
2:31626004		L>Q	A:36	(75.15, 110.01, 130.57)
2:31626000		S>R	A:37	(74.48, 105.61, 132.42)
2:31625984		C>S	A:43	(88.61, 99.77, 139.56)
2:31625977		E>G	A:45	(93.12, 100.43, 140.26)
2:31625966		G>R	A:49	(87.83, 99.26, 131.37)
2:31625932		R>H	A:60	(96.72, 124.26, 117.45)
2:31625929		L>P	A:61	(102.11, 120.76, 115.73)
2:31625923	rs530688886	N>S	A:63	(96.60, 120.89, 110.79)
2:31625919	rs182317768	K>N	A:64	(94.87, 115.50, 111.91)
2:31625914		V>A	A:66	(93.46, 113.22, 116.91)
2:31625915		V>I	A:66	(93.46, 113.22, 116.91)
2:31624192		H>P	A:67	(90.13, 110.24, 116.86)
2:31624189		F>S	A:68	(92.65, 109.68, 122.30)
2:31624180		N>S	A:71	(90.71, 105.47, 131.46)
2:31624168		A>V	A:75	(90.31, 111.93, 133.96)
2:31624169		A>P	A:75	(90.31, 111.93, 133.96)
2:31624166		P>S	A:76	(91.11, 115.16, 135.11)
2:31624159		C>F	A:78	(90.68, 120.53, 134.30)
2:31624125		E>D	A:89	(75.29, 106.73, 125.56)
2:31624112		T>P	A:94	(67.55, 100.34, 120.95)
2:31624105	rs374226297	T>M	A:96	(67.64, 104.49, 116.56)
2:31624101		R>S	A:97	(69.51, 102.31, 112.49)
2:31624103		R>W	A:97	(69.51, 102.31, 112.49)
2:31624091		V>L	A:101	(80.47, 97.39, 117.27)
2:31624088		Q>K	A:102	(76.35, 98.34, 119.50)
2:31621553	rs558892168	K>E	A:107	(73.19, 89.12, 116.79)
2:31621544	rs147286954	G>S	A:110	(79.22, 88.51, 124.44)
2:31621540	COSM3581139	S>Y	A:111	(76.80, 89.71, 126.57)
2:31621532	COSM1494918	G>R	A:114	(76.95, 93.22, 130.80)
2:31621523	rs556797607	T>S	A:117	(79.81, 95.39, 127.22)
2:31621517		G>S	A:119	(84.06, 99.05, 127.07)
2:31621511		V>I	A:121	(81.98, 98.61, 122.52)
2:31621508		M>L	A:122	(84.08, 102.44, 123.07)
2:31621501	rs547147775	M>K	A:124	(86.41, 97.71, 118.37)
2:31621498		Y>C	A:125	(83.71, 103.52, 117.69)
2:31621486		R>Q	A:129	(86.59, 106.89, 113.90)
2:31621487	rs145064943	R>W	A:129	(86.59, 106.89, 113.90)
2:31621478		P>S	A:132	(89.48, 101.17, 108.63)
2:31621475	rs45447191	E>K	A:133	(90.18, 96.94, 106.58)
2:31621471	rs377748577	P>L	A:134	(91.63, 95.63, 111.00)
2:31621460	COSM3581138	E>Q	A:138	(95.80, 95.44, 114.70)
2:31621455		I>M	A:139	(91.30, 93.12, 116.98)
2:31621456		I>T	A:139	(91.30, 93.12, 116.98)
2:31621443		F>L	A:143	(90.22, 94.06, 123.56)
2:31621441		Q>P	A:144	(96.32, 94.53, 126.71)
2:31620583	rs148108999	R>H	A:149	(85.44, 86.58, 136.33)
2:31620584	rs72549369	R>C	A:149	(85.44, 86.58, 136.33)
2:31620574		G>V	A:152	(85.93, 83.67, 128.01)
2:31620560		L>F	A:157	(87.80, 87.58, 119.68)
2:31620547	rs200810102	R>Q	A:161	(87.37, 86.39, 113.10)
2:31620548	rs548839485	R>W	A:161	(87.37, 86.39, 113.10)
2:31620544		T>N	A:162	(83.75, 89.90, 111.26)
2:31610711	rs201332711	P>L	A:206	(82.42, 104.60, 107.54)
2:31610708		T>I	A:207	(80.20, 107.86, 105.93)
2:31609411		D>G	A:221	(92.18, 130.26, 114.84)
2:31609403	rs147533056	R>W	A:224	(96.42, 127.60, 123.44)
2:31609395		Q>H	A:226	(97.51, 131.01, 131.99)
2:31609390	COSM3426390	R>Q	A:228	(93.43, 130.45, 138.58)
2:31609376	rs149487595	R>C	A:233	(90.67, 119.86, 149.05)
2:31609369	rs45469499	T>M	A:235	(94.47, 125.44, 142.66)
2:31609366		W>S	A:236	(94.53, 122.14, 136.94)
2:31609362	rs202199893	I>M	A:237	(97.58, 126.55, 136.87)
2:31609358		A>S	A:239	(100.20, 126.19, 131.02)
2:31609348		L>R	A:242	(108.43, 126.94, 128.56)
2:31609349		L>F	A:242	(108.43, 126.94, 128.56)
2:31609326		K>N	A:249	(108.07, 125.36, 139.58)
2:31609303		L>R	A:257	(104.10, 118.89, 137.33)
2:31609304		L>V	A:257	(104.10, 118.89, 137.33)
2:31609288		T>M	A:262	(98.52, 107.66, 135.65)
2:31609280	rs369387791	G>C	A:265	(95.48, 109.53, 141.11)
2:31606710		I>S	A:266	(96.54, 106.12, 142.28)
2:31606704		M>K	A:268	(94.87, 112.24, 145.12)
2:31606697		F>L	A:270	(93.67, 104.33, 146.43)
2:31606680		P>L	A:276	(97.59, 122.11, 147.18)
2:31606663		A>P	A:282	(100.80, 119.79, 128.18)
2:31606655		I>M	A:284	(104.12, 123.32, 126.49)
2:31606651	rs375277410	E>Q	A:286	(108.82, 123.65, 123.68)
2:31606648	rs138674014	L>V	A:287	(107.16, 119.50, 126.75)
2:31606633		H>N	A:292	(114.56, 112.47, 113.82)
2:31606624	rs142335345	D>N	A:295	(123.46, 110.73, 117.91)
2:31606621		G>S	A:296	(119.22, 110.09, 118.19)
2:31606000		A>D	A:302	(104.66, 115.01, 127.36)
2:31605988		S>T	A:306	(101.33, 106.00, 122.39)
2:31605982		V>G	A:308	(107.35, 106.55, 121.96)
2:31605979		E>G	A:309	(104.97, 102.06, 120.65)
2:31605971	COSM574937	L>V	A:312	(110.52, 103.63, 117.99)
2:31605958		V>A	A:316	(112.80, 99.56, 113.37)
2:31605946	rs200384255	P>R	A:320	(119.96, 100.17, 109.36)
2:31605928		V>G	A:326	(118.24, 100.50, 122.10)
2:31605920		G>R	A:329	(113.73, 97.30, 123.87)
2:31605901	rs201810251	R>H	A:335	(104.78, 93.27, 123.36)
2:31605902		R>C	A:335	(104.78, 93.27, 123.36)
2:31605893		A>P	A:338	(99.37, 98.07, 130.10)
2:31605868	rs142388231	A>V	A:346	(101.21, 108.30, 129.75)
2:31604591		S>F	A:347	(104.28, 110.44, 130.19)
2:31604589	rs192453952	V>I	A:348	(108.04, 109.36, 129.08)
2:31604585	COSM1690407	G>A	A:349	(108.18, 111.61, 131.98)
2:31604579		N>T	A:351	(107.79, 106.28, 134.09)
2:31604576		I>S	A:352	(111.44, 108.94, 133.97)
2:31604553		D>N	A:360	(109.39, 98.27, 133.26)
2:31604541		V>M	A:364	(116.33, 100.33, 129.57)
2:31604534		M>T	A:366	(120.32, 103.08, 133.97)
2:31604535		M>V	A:366	(120.32, 103.08, 133.97)
2:31604527		S>R	A:368	(121.14, 102.97, 127.41)
2:31604528		S>I	A:368	(121.14, 102.97, 127.41)
2:31604525		G>E	A:369	(122.55, 105.65, 128.56)
2:31604514		T>A	A:373	(117.21, 118.01, 128.88)
2:31604502		R>G	A:377	(113.83, 131.94, 136.35)
2:31602827		V>A	A:383	(122.36, 114.10, 132.77)
2:31602805	rs146169510	F>L	A:390	(117.28, 106.85, 140.28)
2:31602791	rs34929837	K>M	A:395	(114.39, 111.00, 146.36)
2:31602776	rs140879910	P>L	A:400	(112.88, 121.84, 143.65)
2:31602769		E>D	A:402	(115.45, 121.49, 138.01)
2:31602767	COSM270561	I>T	A:403	(111.37, 120.98, 134.40)
2:31602765	rs372033714	L>M	A:404	(112.19, 116.64, 132.35)
2:31602750		I>F	A:409	(116.43, 106.88, 122.89)
2:31602743		Y>C	A:411	(120.76, 106.23, 116.49)
2:31600090		S>L	A:419	(118.36, 92.77, 125.81)
2:31600091		S>P	A:419	(118.36, 92.77, 125.81)
2:31600076		A>P	A:424	(105.08, 88.57, 135.98)
2:31600072	rs138649664	S>C	A:425	(101.67, 87.19, 136.89)
2:31600056	rs566687319	D>E	A:430	(105.86, 99.18, 144.88)
2:31600047	rs370440638	K>N	A:433	(108.23, 92.29, 139.21)
2:31600043		T>A	A:435	(112.74, 94.67, 135.40)
2:31600032		M>I	A:438	(120.92, 93.42, 129.94)
2:31600027		V>D	A:440	(127.63, 94.46, 125.55)
2:31600023		L>F	A:441	(130.89, 97.36, 123.58)
2:31600010		T>A	A:446	(137.02, 91.28, 118.37)
2:31599998		Q>E	A:450	(135.41, 98.62, 125.84)
2:31599994		E>G	A:451	(131.31, 99.62, 127.39)
2:31599989	rs185036611	A>T	A:453	(125.68, 97.03, 131.94)
2:31599973		G>A	A:458	(113.07, 94.90, 142.14)
2:31599971		M>V	A:459	(115.96, 93.20, 143.47)
2:31599960		R>S	A:462	(117.73, 102.11, 144.63)
2:31599944		K>E	A:468	(131.22, 95.02, 142.84)
2:31599928		Q>R	A:473	(133.68, 90.35, 134.01)
2:31598392	COSM721248 COSM304765	V>M	A:486	(128.47, 86.84, 136.05)
2:31598388		C>Y	A:487	(126.28, 84.01, 138.00)
2:31598371		E>K	A:493	(126.41, 92.75, 144.40)
2:31598355		P>L	A:498	(114.98, 86.42, 154.81)
2:31598347		P>S	A:501	(110.42, 93.64, 151.34)
2:31598337	rs372497202	M>T	A:504	(108.49, 85.63, 146.28)
2:31598331		D>G	A:506	(114.50, 81.86, 146.39)
2:31598325	rs148603901	R>Q	A:508	(112.84, 88.95, 144.74)
2:31598326		R>W	A:508	(112.84, 88.95, 144.74)
2:31598313	rs74874345	T>I	A:512	(118.88, 87.64, 138.58)
2:31598284		T>A	A:522	(120.91, 85.97, 122.77)
2:31598269		L>M	A:527	(128.46, 86.28, 116.91)
2:31598265		G>D	A:528	(129.63, 83.00, 116.41)
2:31598263	COSM4093820	Q>K	A:529	(126.47, 80.19, 115.85)
2:31598259		E>G	A:530	(128.10, 77.80, 119.36)
2:31598251	rs147476468	E>K	A:533	(122.75, 70.80, 111.59)
2:31596748	rs183162063	Q>H	A:559	(82.00, 75.92, 118.90)
2:31596746		L>H	A:560	(79.87, 70.74, 118.44)
2:31596747		L>V	A:560	(79.87, 70.74, 118.44)
2:31596740		Q>P	A:562	(71.65, 67.68, 119.19)
2:31595241		E>V	A:570	(60.11, 77.74, 113.06)
2:31595236		D>H	A:572	(59.15, 75.54, 119.90)
2:31595231		M>I	A:573	(62.28, 78.88, 120.48)
2:31595233		M>V	A:573	(62.28, 78.88, 120.48)
2:31595223		R>Q	A:576	(65.31, 76.44, 118.10)
2:31595224	rs139772558	R>W	A:576	(65.31, 76.44, 118.10)
2:31595208		L>P	A:581	(65.78, 88.38, 126.38)
2:31595205	rs536702980	A>V	A:582	(69.15, 91.93, 126.93)
2:31595199	rs45491693	D>A	A:584	(70.70, 94.44, 122.05)
2:31595200		D>N	A:584	(70.70, 94.44, 122.05)
2:31595184		G>V	A:589	(73.56, 101.16, 127.66)
2:31595179		A>T	A:591	(70.75, 98.63, 130.70)
2:31595176	rs141314828	V>M	A:592	(69.27, 99.77, 134.31)
2:31595157		P>L	A:598	(67.89, 107.65, 139.31)
2:31595154	rs200795066 COSM721249 COSM1641902	R>H	A:599	(70.88, 110.19, 143.38)
2:31595155	rs558003041 COSM3581118	R>C	A:599	(70.88, 110.19, 143.38)
2:31595152		Y>N	A:600	(64.51, 110.16, 144.83)
2:31595144		N>K	A:602	(66.08, 113.82, 149.16)
2:31595143	COSM3581117	E>K	A:603	(69.31, 110.10, 147.39)
2:31595133		L>P	A:606	(76.71, 105.34, 153.21)
2:31595131	rs201464771	R>W	A:607	(82.15, 105.82, 152.48)
2:31595127		L>R	A:608	(81.25, 101.47, 155.69)
2:31595113	rs201668777	R>W	A:613	(94.31, 97.20, 165.16)
2:31595099	rs45442398	K>N	A:617	(89.10, 96.11, 174.38)
2:31593342	rs371877914	S>C	A:620	(87.36, 105.50, 172.12)
2:31593340		I>V	A:621	(84.80, 106.35, 168.69)
2:31593333	rs45448694	T>I	A:623	(83.38, 112.42, 165.75)
2:31593331		S>P	A:624	(85.97, 115.81, 165.79)
2:31593305	rs149593992	F>L	A:632	(78.74, 115.15, 158.69)
2:31593288		A>V	A:638	(75.63, 100.32, 167.53)
2:31593289	rs202112369 COSM4141066	A>T	A:638	(75.63, 100.32, 167.53)
2:31593285		D>G	A:639	(74.40, 102.74, 170.50)
2:31593279		V>D	A:641	(69.93, 99.53, 166.39)
2:31593244		E>K	A:653	(77.57, 88.49, 162.21)
2:31593224		D>E	A:659	(82.47, 96.20, 173.56)
2:31591526		V>I	A:661	(87.41, 94.16, 166.88)
2:31591519		C>Y	A:663	(88.55, 90.89, 161.87)
2:31591517	rs201301387	V>I	A:664	(91.09, 93.01, 159.38)
2:31591510		H>R	A:666	(83.98, 94.04, 162.23)
2:31591511		H>Y	A:666	(83.98, 94.04, 162.23)
2:31591507		I>T	A:667	(81.25, 96.95, 160.08)
2:31591499		A>T	A:670	(78.78, 104.92, 159.29)
2:31591495		V>G	A:671	(79.76, 108.29, 157.56)
2:31591489		A>V	A:673	(76.71, 112.57, 153.11)
2:31591483		T>N	A:675	(79.04, 113.70, 148.18)
2:31591480	COSM3581113	P>L	A:676	(80.66, 110.49, 147.26)
2:31591476		E>D	A:677	(83.49, 112.94, 146.68)
2:31591462		A>D	A:682	(84.50, 111.65, 156.76)
2:31591456		Q>R	A:684	(89.86, 109.71, 156.77)
2:31591447		K>R	A:687	(91.26, 108.81, 165.37)
2:31591441	rs542860902	T>I	A:689	(91.45, 104.22, 170.56)
2:31591433		E>K	A:692	(96.63, 94.59, 170.56)
2:31591423	rs142001530	A>V	A:695	(95.73, 86.31, 167.02)
2:31591415		T>P	A:698	(97.24, 80.17, 160.62)
2:31591412		I>F	A:699	(94.90, 76.61, 159.14)
2:31590922	rs527413763	D>V	A:701	(97.57, 78.56, 164.60)
2:31590916	rs142848703	I>K	A:703	(95.15, 72.87, 165.04)
2:31590917	rs17011368	I>V	A:703	(95.15, 72.87, 165.04)
2:31590907	rs532403349	N>S	A:706	(91.30, 73.41, 170.05)
2:31590898	rs146345594	Y>C	A:709	(83.29, 77.75, 164.01)
2:31590878	rs267599347 COSM3910237	E>K	A:716	(83.61, 55.22, 157.97)
2:31590867		D>E	A:719	(87.34, 47.39, 157.09)
2:31590856	COSM337798 COSM3910236	G>A	A:723	(93.28, 47.30, 153.89)
2:31590851		S>A	A:725	(96.88, 44.53, 155.16)
2:31589858		E>K	A:734	(100.65, 67.68, 153.42)
2:31589846	COSM3972223	G>S	A:738	(93.91, 78.12, 147.64)
2:31589822		E>K	A:746	(77.46, 95.07, 139.98)
2:31589812		C>Y	A:749	(74.56, 97.88, 146.25)
2:31589810		T>P	A:750	(71.73, 99.43, 148.86)
2:31589806		I>T	A:751	(68.99, 102.19, 146.38)
2:31589789	rs370126462	E>K	A:757	(52.78, 105.44, 155.78)
2:31589786		A>T	A:758	(54.10, 101.92, 159.10)
2:31589777		M>V	A:761	(61.79, 100.51, 153.91)
2:31589765		V>M	A:765	(69.42, 95.00, 146.39)
2:31589761		S>C	A:766	(72.92, 93.30, 144.19)
2:31589759	rs367726228	T>A	A:767	(70.80, 89.99, 145.82)
2:31588968		V>A	A:777	(66.15, 94.46, 157.35)
2:31588957		L>M	A:781	(64.32, 97.98, 161.72)
2:31588954	rs544529260	G>R	A:782	(61.63, 95.88, 164.47)
2:31588951	rs138717520	V>I	A:783	(59.56, 95.60, 161.79)
2:31588948	rs141938849	P>S	A:784	(56.67, 93.54, 160.68)
2:31588940	rs575845178	N>K	A:786	(54.41, 93.08, 156.35)
2:31588938	rs149717617	R>Q	A:787	(55.10, 96.63, 157.66)
2:31588939	rs148904866	R>W	A:787	(55.10, 96.63, 157.66)
2:31588935		I>T	A:788	(60.13, 95.05, 154.19)
2:31588936	rs141050887	I>F	A:788	(60.13, 95.05, 154.19)
2:31588926	rs143887178	R>Q	A:791	(62.14, 96.12, 143.81)
2:31588924		V>L	A:792	(66.30, 92.22, 142.13)
2:31588906	COSM1668835	G>S	A:798	(77.95, 86.36, 141.87)
2:31588884		R>Q	A:805	(78.47, 88.63, 153.83)
2:31588885	rs140007233	R>W	A:805	(78.47, 88.63, 153.83)
2:31588878		T>I	A:807	(73.22, 91.43, 154.17)
2:31588872		V>G	A:809	(75.67, 96.85, 152.78)
2:31588866	rs372844459 COSM4093812	T>M	A:811	(71.93, 96.33, 157.23)
2:31588861	rs142951412	V>L	A:813	(71.75, 101.48, 154.01)
2:31588857	rs148585342	A>V	A:814	(68.48, 100.94, 156.17)
2:31588845		Y>C	A:818	(64.79, 104.56, 161.66)
2:31588846	rs139272198	Y>H	A:818	(64.79, 104.56, 161.66)
2:31588406		G>S	A:821	(63.91, 109.90, 156.42)
2:31588402		R>H	A:822	(66.81, 112.20, 153.59)
2:31588403		R>C	A:822	(66.81, 112.20, 153.59)
2:31588399		P>R	A:823	(66.52, 108.78, 150.56)
2:31588396		V>A	A:824	(70.24, 106.27, 151.58)
2:31588393	COSM327549	R>Q	A:825	(72.36, 105.56, 146.38)
2:31588390	rs150297607	C>Y	A:826	(75.84, 102.55, 149.11)
2:31588388		M>V	A:827	(78.63, 101.11, 145.11)
2:31588378		R>H	A:830	(86.56, 96.11, 143.32)
2:31588379	COSM1483056	R>C	A:830	(86.56, 96.11, 143.32)
2:31588368		D>E	A:833	(84.28, 94.44, 147.99)
2:31588365		M>I	A:834	(88.73, 92.59, 147.67)
2:31588366		M>T	A:834	(88.73, 92.59, 147.67)
2:31588367		M>V	A:834	(88.73, 92.59, 147.67)
2:31588357		T>S	A:837	(82.93, 90.35, 151.32)
2:31588342		P>R	A:842	(91.21, 77.94, 152.23)
2:31588340		F>L	A:843	(90.20, 73.08, 152.02)
2:31587100	rs548580818	M>K	A:852	(97.30, 46.48, 144.32)
2:31587101		M>L	A:852	(97.30, 46.48, 144.32)
2:31587091		G>E	A:855	(96.53, 50.17, 140.07)
2:31587088		T>I	A:856	(93.76, 48.46, 141.41)
2:31587080		A>T	A:859	(92.45, 52.04, 150.55)
2:31587073		E>G	A:861	(93.05, 57.92, 155.79)
2:31587066		D>E	A:863	(92.19, 64.30, 157.20)
2:31587055	rs374758075	N>S	A:867	(90.23, 79.09, 157.02)
2:31587043		T>I	A:871	(81.34, 84.15, 160.79)
2:31587035	rs371771297	L>F	A:874	(76.98, 78.73, 154.43)
2:31573086		M>V	A:879	(83.48, 70.44, 154.70)
2:31573079	COSM286557	R>Q	A:881	(78.78, 69.73, 147.90)
2:31573076	rs199624952	A>G	A:882	(83.52, 68.05, 150.15)
2:31573077		A>S	A:882	(83.52, 68.05, 150.15)
2:31573067		H>R	A:885	(82.25, 65.44, 145.54)
2:31573061	rs145291309	D>G	A:887	(84.59, 60.14, 144.68)
2:31573037	rs139272445	I>N	A:895	(86.49, 55.35, 152.33)
2:31573034		R>Q	A:896	(88.46, 57.81, 158.22)
2:31573025		G>A	A:899	(86.45, 67.54, 159.06)
2:31573022		R>Q	A:900	(87.18, 70.11, 162.81)
2:31573023		R>W	A:900	(87.18, 70.11, 162.81)
2:31572992	rs669884	T>M	A:910	(81.17, 82.59, 151.54)
2:31572984		R>W	A:913	(80.97, 79.05, 139.52)
2:31572980	rs372422786	G>D	A:914	(81.33, 74.83, 143.84)
2:31572977		F>S	A:915	(78.95, 75.06, 148.00)
2:31572975		G>R	A:916	(83.93, 72.49, 147.61)
2:31572948		E>K	A:925	(92.91, 63.66, 140.72)
2:31572939		M>V	A:928	(95.10, 58.85, 141.10)
2:31572935		S>N	A:929	(98.86, 60.98, 139.80)
2:31572927	rs141291583	A>T	A:932	(100.44, 56.16, 138.20)
2:31572917		C>S	A:935	(103.06, 51.81, 139.20)
2:31572912		M>V	A:937	(102.75, 55.08, 133.61)
2:31572906		A>P	A:939	(97.66, 57.78, 133.33)
2:31572903		E>K	A:940	(94.23, 56.36, 130.27)
2:31572693	rs138396004	R>Q	A:943	(93.01, 58.59, 135.80)
2:31572694	rs144514609	R>W	A:943	(93.01, 58.59, 135.80)
2:31572670	rs142675390	G>R	A:951	(75.11, 50.87, 139.27)
2:31572667		D>N	A:952	(78.16, 50.91, 140.98)
2:31572658		H>Y	A:955	(81.27, 57.77, 149.47)
2:31572653		F>L	A:956	(76.95, 58.97, 149.21)
2:31572651		N>I	A:957	(75.24, 54.01, 150.14)
2:31572648		Q>R	A:958	(73.10, 57.83, 145.62)
2:31572640		E>K	A:961	(70.27, 55.44, 138.19)
2:31572621		R>I	A:967	(78.41, 58.41, 125.65)
2:31572619		C>G	A:968	(82.17, 61.44, 127.98)
2:31572613		E>K	A:970	(85.76, 56.10, 125.17)
2:31572610	rs148921536	E>K	A:971	(82.63, 61.21, 122.40)
2:31572588		Y>C	A:978	(95.97, 61.25, 125.11)
2:31572586		H>N	A:979	(96.49, 57.93, 122.11)
2:31572583		A>P	A:980	(99.27, 60.96, 119.25)
2:31572580	COSM1407729	R>W	A:981	(97.90, 65.94, 120.98)
2:31572565	rs367710339	D>N	A:986	(107.18, 62.56, 124.44)
2:31572552		K>R	A:990	(114.52, 63.83, 122.70)
2:31571843		E>D	A:991	(113.95, 68.01, 119.77)
2:31571845	COSM1690400	E>K	A:991	(113.95, 68.01, 119.77)
2:31571838		C>F	A:993	(116.70, 71.96, 127.02)
2:31571815		I>V	A:1001	(92.69, 63.15, 130.46)
2:31571785		T>S	A:1011	(72.18, 69.90, 151.04)
2:31571222	rs536923494	A>D	A:1020	(55.15, 81.67, 140.27)
2:31571213		H>R	A:1023	(49.46, 88.35, 135.86)
2:31571214		H>Y	A:1023	(49.46, 88.35, 135.86)
2:31571211		V>M	A:1024	(46.70, 87.17, 130.99)
2:31571198	rs571418792 COSM3407822	G>A	A:1028	(47.17, 89.12, 125.28)
2:31571180		H>L	A:1034	(60.86, 83.92, 138.20)
2:31571178		G>R	A:1035	(62.03, 83.73, 142.12)
2:31571171		T>I	A:1037	(67.86, 86.25, 140.37)
2:31571165		M>T	A:1039	(73.49, 86.25, 138.07)
2:31571157		G>R	A:1042	(69.49, 83.11, 131.36)
2:31571148	rs142402298	T>A	A:1045	(66.07, 83.67, 128.32)
2:31571139		V>I	A:1048	(60.49, 82.87, 128.16)
2:31570516		V>M	A:1050	(59.35, 77.04, 129.05)
2:31570510		S>G	A:1052	(56.45, 79.65, 124.82)
2:31570501		L>V	A:1055	(51.16, 78.89, 126.77)
2:31570481		K>N	A:1061	(52.75, 87.42, 122.44)
2:31570476		Y>C	A:1063	(58.67, 91.77, 129.64)
2:31570474		I>V	A:1064	(60.27, 88.72, 132.65)
2:31570468		E>K	A:1066	(61.12, 93.14, 138.69)
2:31570464		T>I	A:1067	(62.69, 89.73, 141.02)
2:31570461	rs186225688	S>N	A:1068	(59.64, 90.63, 144.03)
2:31570459	rs146283435	T>A	A:1069	(59.34, 90.44, 148.05)
2:31570454		N>K	A:1070	(55.40, 91.72, 146.33)
2:31570456		N>D	A:1070	(55.40, 91.72, 146.33)
2:31570431		T>M	A:1078	(69.57, 82.51, 143.04)
2:31570420		V>L	A:1082	(68.71, 74.22, 140.89)
2:31570410		D>V	A:1085	(65.64, 72.89, 137.34)
2:31570404	rs370788512	N>S	A:1087	(62.01, 78.55, 138.79)
2:31570405	rs374248574	N>D	A:1087	(62.01, 78.55, 138.79)
2:31570399		Q>E	A:1089	(58.59, 72.53, 137.19)
2:31569708	rs553426035	A>V	A:1093	(52.07, 75.01, 136.65)
2:31569705		A>V	A:1094	(50.98, 78.17, 135.97)
2:31569677		E>D	A:1103	(39.90, 73.54, 126.86)
2:31569676	rs558670995	P>S	A:1104	(36.27, 75.93, 127.48)
2:31569660	rs45547640	N>T	A:1109	(36.77, 79.23, 118.13)
2:31567596		A>T	A:1120	(36.22, 85.41, 125.86)
2:31567592		A>D	A:1121	(37.00, 84.56, 129.18)
2:31567590		Y>H	A:1122	(36.95, 90.04, 130.99)
2:31567586		M>T	A:1123	(33.13, 89.06, 128.22)
2:31565155		N>S	A:1138	(61.94, 61.10, 147.42)
2:31565152		L>R	A:1139	(65.56, 64.72, 148.67)
2:31565142		S>R	A:1142	(71.64, 60.64, 157.53)
2:31565136	rs200349996	E>D	A:1144	(73.86, 59.75, 162.00)
2:31565134		T>I	A:1145	(72.59, 56.20, 158.72)
2:31565126		G>R	A:1148	(69.85, 58.14, 151.76)
2:31565121		N>K	A:1149	(68.82, 60.22, 148.57)
2:31565119	rs1042036	P>R	A:1150	(71.64, 63.36, 148.71)
2:31565101		Y>C	A:1156	(78.04, 62.69, 134.90)
2:31565086		S>C	A:1161	(94.88, 70.00, 128.41)
2:31565080	rs142988357	V>A	A:1163	(100.77, 72.95, 128.56)
2:31565057		D>N	A:1171	(105.51, 81.98, 131.33)
2:31565053		H>R	A:1172	(101.77, 78.98, 131.24)
2:31564256		L>R	A:1175	(99.09, 75.02, 123.49)
2:31564253	rs529891514	R>H	A:1176	(94.08, 71.38, 121.76)
2:31564254	rs45624433	R>C	A:1176	(94.08, 71.38, 121.76)
2:31564250	rs148972840	T>I	A:1177	(91.44, 72.61, 125.64)
2:31564244	rs139515054	I>T	A:1179	(85.45, 70.16, 126.90)
2:31564241		V>A	A:1180	(82.83, 66.31, 126.46)
2:31564238	rs373259977	M>K	A:1181	(79.62, 68.49, 129.40)
2:31564223		S>I	A:1186	(69.79, 72.10, 125.91)
2:31562543		V>L	A:1196	(81.01, 75.50, 129.69)
2:31562534		A>T	A:1199	(83.63, 78.06, 134.36)
2:31562521		G>D	A:1203	(89.71, 77.66, 136.99)
2:31562515		G>A	A:1205	(92.53, 80.94, 137.99)
2:31562500		E>A	A:1210	(93.36, 83.92, 141.10)
2:31562482	rs143981573	P>H	A:1216	(102.05, 88.76, 159.28)
2:31562483	COSM3581091	P>S	A:1216	(102.05, 88.76, 159.28)
2:31562480	rs202023189 COSM3798957	E>K	A:1217	(100.05, 91.37, 161.40)
2:31562464	rs148235835	T>I	A:1222	(95.72, 91.58, 147.78)
2:31562461	COSM1306715	R>H	A:1223	(93.02, 95.96, 149.35)
2:31562462	rs116290580	R>C	A:1223	(93.02, 95.96, 149.35)
2:31562452		S>N	A:1226	(97.07, 95.52, 140.14)
2:31562437		P>L	A:1231	(91.77, 85.66, 133.72)
2:31562419	rs200177886	P>L	A:1237	(92.77, 78.50, 125.66)
2:31562416		I>T	A:1238	(95.52, 78.93, 121.53)
2:31562405	rs183714440	V>M	A:1242	(83.17, 72.95, 123.51)
2:31562392	rs140606023	R>H	A:1246	(74.72, 63.93, 119.93)
2:31562393	rs142329784	R>C	A:1246	(74.72, 63.93, 119.93)
2:31562390	rs369981553	D>N	A:1247	(71.27, 61.15, 121.54)
2:31562367		I>M	A:1254	(62.27, 71.05, 132.94)
2:31562365	rs147253350	Y>F	A:1255	(60.12, 70.69, 128.66)
2:31560670		P>L	A:1263	(79.78, 71.28, 137.09)
2:31560667		P>R	A:1264	(82.10, 72.78, 134.51)
2:31560668	COSM4093807	P>T	A:1264	(82.10, 72.78, 134.51)
2:31560652		A>V	A:1269	(92.54, 70.56, 136.31)
2:31560649		S>C	A:1270	(93.61, 69.74, 133.03)
2:31560646		I>T	A:1271	(95.64, 73.44, 132.66)
2:31560647		I>V	A:1271	(95.64, 73.44, 132.66)
2:31560619		R>H	A:1280	(107.61, 64.65, 136.57)
2:31560620		R>C	A:1280	(107.61, 64.65, 136.57)
2:31560610	COSM3798956	R>Q	A:1283	(112.52, 67.88, 138.88)
2:31560601		H>L	A:1286	(118.38, 70.22, 134.14)
2:31560589		N>S	A:1290	(115.94, 61.80, 140.59)
2:31560587	rs191740294	V>M	A:1291	(113.66, 56.94, 139.89)
2:31560583	rs73922346	K>R	A:1292	(109.61, 55.97, 140.22)
2:31560581		E>Q	A:1293	(110.60, 62.40, 142.00)
2:31560574		F>C	A:1295	(106.99, 66.91, 142.60)
2:31560571	rs139691722	R>Q	A:1296	(104.04, 69.90, 148.59)
2:31560572	rs45564939	R>W	A:1296	(104.04, 69.90, 148.59)
2:31560561		S>R	A:1299	(96.87, 75.67, 144.55)
2:31560562		S>N	A:1299	(96.87, 75.67, 144.55)
2:31560557		A>T	A:1301	(100.44, 77.40, 139.69)
2:31560550		P>L	A:1303	(105.02, 81.93, 137.96)
2:31560538	rs138249576	R>H	A:1307	(112.19, 78.53, 137.83)
2:31560539	rs371280381	R>C	A:1307	(112.19, 78.53, 137.83)
2:31560535		N>S	A:1308	(110.89, 77.80, 142.66)
2:31560524		D>N	A:1312	(118.90, 74.63, 137.87)
2:31560521	rs141335716	K>E	A:1313	(123.55, 75.31, 136.49)
2:31560516	rs376342473	F>L	A:1314	(121.01, 78.83, 137.35)
2:31560515		T>A	A:1315	(118.36, 76.62, 142.10)

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:31621561	COSM1690414	R>K	A:104	(78.71, 92.61, 114.21)
2:31621549	COSM1690413	S>N	A:108	(77.81, 86.55, 119.15)
2:31621532	COSM1494918	G>R	A:114	(76.95, 93.22, 130.80)
2:31620593	COSM1159318	N>H	A:146	(89.17, 95.67, 128.38)
2:31620554	COSM2157159	G>C	A:159	(82.65, 88.26, 116.33)
2:31620539	COSM3426391	A>T	A:164	(89.29, 91.53, 109.48)
2:31609390	COSM3426390	R>Q	A:228	(93.43, 130.45, 138.58)
2:31606681	COSM3581133	P>S	A:276	(97.59, 122.11, 147.18)
2:31606641	COSM1020134	S>L	A:289	(109.02, 117.47, 120.62)
2:31605980	COSM3581131	E>K	A:309	(104.97, 102.06, 120.65)
2:31605974	COSM2941922	T>P	A:311	(108.22, 106.62, 116.53)
2:31598392	COSM721248	V>L	A:486	(128.47, 86.84, 136.05)
2:31595112	COSM1288980	R>Q	A:613	(94.31, 97.20, 165.16)
2:31593289	COSM4141066	A>T	A:638	(75.63, 100.32, 167.53)
2:31589851	COSM1717261	Y>F	A:736	(97.45, 75.41, 150.96)
2:31588906	COSM1668835	G>C	A:798	(77.95, 86.36, 141.87)
2:31588885	COSM1581953	R>W	A:805	(78.47, 88.63, 153.83)
2:31588393	COSM327549	R>Q	A:825	(72.36, 105.56, 146.38)
2:31588330	COSM1194873	R>T	A:846	(97.16, 66.16, 156.90)
2:31573079	COSM286557	R>Q	A:881	(78.78, 69.73, 147.90)
2:31573035	COSM1407731	R>W	A:896	(88.46, 57.81, 158.22)
2:31572998	COSM1721000	S>F	A:908	(83.76, 85.36, 156.59)
2:31572694	COSM1579986	R>W	A:943	(93.01, 58.59, 135.80)
2:31572645	COSM1270556	K>T	A:959	(71.71, 53.17, 142.25)
2:31572580	COSM1407729	R>W	A:981	(97.90, 65.94, 120.98)
2:31571184	COSM1407728	T>A	A:1033	(57.28, 86.59, 138.10)
2:31570422	COSM1690398	S>F	A:1081	(72.50, 74.99, 139.57)
2:31570414	COSM1020122	A>T	A:1084	(66.35, 76.39, 136.37)
2:31569684	COSM1531741	R>T	A:1101	(41.55, 78.97, 134.59)
2:31567595	COSM2941839	A>V	A:1120	(36.22, 85.41, 125.86)
2:31564236	COSM1690397	D>N	A:1182	(76.00, 65.65, 130.36)
2:31562483	COSM3581091	P>S	A:1216	(102.05, 88.76, 159.28)
2:31562393	COSM721258	R>C	A:1246	(74.72, 63.93, 119.93)
2:31560548	COSM1720999	E>K	A:1304	(106.98, 81.60, 143.14)
2:31560521	COSM1581952	K>E	A:1313	(123.55, 75.31, 136.49)