General Structure Information
| PDB ID | 2coj |
| HGNC Gene Label(s) | BCAT1 |
| Structure Name | crystal structure of reduced human cytosolic branched-chain aminotransferase complexed with gabapentin |
| Resolution | 2.4Å |
| Reference | AUTH M.GOTO,I.MIYAHARA,K.HIROTSU,M.CONWAY,N.YENNAWAR,M.M.ISLAM,AUTH 2 S.M.HUTSONTITL STRUCTURAL DETERMINANTS FOR BRANCHED-CHAIN AMINOTRANSFERASETITL 2 ISOZYME-SPECIFIC INHIBITION BY THE ANTICONVULSANT DRUGTITL 3 GABAPENTINREF J.BIOL.CHEM. V. 280 37246 2005REFN ISSN 0021-9258PMID 16141215DOI 10.1074/JBC.M506486200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 358 |
| Number Of SNVs | 92 |
| Number Of Permutations | 42712 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.015 |
| p-value | 0.453 |
COSMIC
| Number Of Residues | 358 |
| Number Of SNVs | 7 |
| Number Of Permutations | 2443 |
| Optimal Distance Threshold | 32.0 |
| K Statistic | 0.476 |
| p-value | 0.704 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 92 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 33.0 |
| K Statistic | -0.297 |
| p-value | 0.782 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
