General Structure Information
| PDB ID | 2h11 |
| HGNC Gene Label(s) | TPMT |
| Structure Name | amino-terminal truncated thiopurine s-methyltransferase complexed with s-adenosyl-l-homocysteine |
| Resolution | 1.89Å |
| Reference | AUTH J.R.HORTON,X.CHENGTITL AMINO-TERMINAL TRUNCATED THIOPURINETITL 2 S-METHYLTRANSFERASE COMPLEXED WITHTITL 3 S-ADENOSYL-L-HOMOCYSTEINEREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 229 |
| Number Of SNVs | 62 |
| Number Of Permutations | 5769 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.032 |
| p-value | 0.412 |
ClinVar
| Number Of Residues | 229 |
| Number Of SNVs | 4 |
| Number Of Permutations | 230 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.667 |
| p-value | 0.156 |
COSMIC
| Number Of Residues | 229 |
| Number Of SNVs | 4 |
| Number Of Permutations | 110 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.167 |
| p-value | 0.027 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 62 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.328 |
| p-value | 0.179 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 62 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.16 |
| p-value | 0.07 |