General Structure Information
| PDB ID | 2aot |
| HGNC Gene Label(s) | HNMT |
| Structure Name | histamine methyltransferase complexed with the antihistamine drug diphenhydramine |
| Resolution | 1.9Å |
| Reference | AUTH J.R.HORTON,K.SAWADA,M.NISHIBORI,X.CHENGTITL STRUCTURAL BASIS FOR INHIBITION OF HISTAMINETITL 2 N-METHYLTRANSFERASE BY DIVERSE DRUGSREF J.MOL.BIOL. V. 353 334 2005REFN ISSN 0022-2836PMID 16168438DOI 10.1016/J.JMB.2005.08.040 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 286 |
| Number Of SNVs | 82 |
| Number Of Permutations | 13444 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.048 |
| p-value | 0.806 |
COSMIC
| Number Of Residues | 286 |
| Number Of SNVs | 3 |
| Number Of Permutations | 207 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.333 |
| p-value | 0.878 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
