3PFF.A | ACLY – ASTRID

3PFF.A | ACLY

General Structure Information

PDB ID	3pff
HGNC Gene Label(s)	ACLY
Structure Name	truncated human atp-citrate lyase with adp and tartrate bound
Resolution	2.3Å
Reference	AUTH T.SUN,K.HAYAKAWA,M.E.FRASERTITL ADP-MG2+ BOUND TO THE ATP-GRASP DOMAIN OF ATP-CITRATE LYASE.REF ACTA CRYSTALLOGR.,SECT.F V. 67 1168 2011REFN ESSN 1744-3091PMID 22102020DOI 10.1107/S1744309111028363

Variant Set Distributions

ExAC Variants

Number Of Residues	735
Number Of SNVs	172
Number Of Permutations	38801
Optimal Distance Threshold	12.0
K Statistic	0.041
p-value	0.886

COSMIC

Number Of Residues	735
Number Of SNVs	7
Number Of Permutations	4393
Optimal Distance Threshold	20.0
K Statistic	0.238
p-value	0.536

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	172
Number Of COSMIC SNVs	7
Optimal Distance Threshold	20.0
K Statistic	0.087
p-value	0.724

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
17:40070122		S>L	A:2	(32.68, 40.93, 35.13)
17:40070111	rs367736290 COSM1520932	I>V	A:6	(37.50, 43.24, 46.24)
17:40070098	COSM186918	T>M	A:10	(42.11, 43.17, 48.90)
17:40070066		T>A	A:21	(48.80, 61.22, 48.14)
17:40070062		T>I	A:22	(50.57, 64.79, 49.14)
17:40070057		A>T	A:24	(48.84, 61.66, 55.27)
17:40070048		N>H	A:27	(47.36, 52.99, 60.30)
17:40070035		Y>C	A:31	(46.06, 44.79, 57.26)
17:40070029	rs200246689	R>Q	A:33	(42.68, 36.81, 57.56)
17:40070021		P>S	A:36	(38.44, 29.62, 62.54)
17:40070002		R>H	A:42	(51.30, 31.70, 63.56)
17:40070003		R>C	A:42	(51.30, 31.70, 63.56)
17:40068773		Q>R	A:61	(32.27, 37.73, 54.99)
17:40068771		L>V	A:62	(30.96, 41.14, 50.91)
17:40068768		I>V	A:63	(28.53, 41.99, 55.59)
17:40068762		R>C	A:65	(23.93, 48.73, 56.24)
17:40068758		R>H	A:66	(30.25, 45.88, 59.05)
17:40068750		L>F	A:69	(24.06, 44.59, 61.91)
17:40068732	rs1058875	N>D	A:75	(37.94, 50.99, 71.97)
17:40068729		L>F	A:76	(38.24, 46.41, 72.07)
17:40068718		D>E	A:79	(42.25, 40.21, 75.80)
17:40068710	COSM4066475	K>T	A:82	(40.76, 36.71, 72.14)
17:40068707		S>F	A:83	(35.67, 38.29, 74.03)
17:40068692	rs574241105	R>Q	A:88	(30.26, 37.41, 67.77)
17:40068693	rs41280076	R>W	A:88	(30.26, 37.41, 67.77)
17:40068677	rs376094175	A>D	A:93	(24.56, 34.81, 60.51)
17:40068678		A>T	A:93	(24.56, 34.81, 60.51)
17:40068674		T>I	A:94	(20.99, 36.27, 59.29)
17:40066524		T>I	A:99	(22.33, 32.45, 56.15)
17:40066511		K>N	A:103	(34.68, 32.06, 57.64)
17:40066489	rs541819037	V>I	A:111	(40.95, 55.84, 64.99)
17:40066485		P>L	A:112	(40.85, 58.26, 67.92)
17:40065942		F>L	A:119	(34.69, 63.40, 56.07)
17:40065938		V>L	A:121	(34.42, 58.93, 49.21)
17:40065928	rs558283153	Y>C	A:124	(29.31, 55.56, 40.24)
17:40065919	rs140011228	R>Q	A:127	(27.79, 53.88, 27.79)
17:40065914		G>R	A:129	(31.69, 57.62, 33.32)
17:40065905	COSM979374	V>I	A:132	(33.29, 61.61, 42.10)
17:40065888		E>D	A:137	(27.47, 64.69, 57.25)
17:40065889		E>A	A:137	(27.47, 64.69, 57.25)
17:40065890		E>K	A:137	(27.47, 64.69, 57.25)
17:40065886		G>A	A:138	(29.81, 60.41, 57.55)
17:40065875		V>M	A:142	(25.21, 58.67, 55.18)
17:40065868	rs200166376	D>A	A:144	(19.97, 58.73, 50.05)
17:40065860	rs146278746	A>T	A:147	(20.71, 62.48, 47.19)
17:40065833		V>L	A:156	(35.17, 59.04, 28.49)
17:40065809		D>Y	A:164	(36.21, 70.97, 39.69)
17:40065802		K>I	A:166	(39.44, 72.59, 45.77)
17:40065781		A>G	A:173	(33.87, 71.19, 53.77)
17:40065778		P>L	A:174	(35.72, 71.54, 56.57)
17:40065306		F>L	A:184	(42.55, 60.81, 49.44)
17:40065298		G>A	A:187	(44.46, 59.89, 44.18)
17:40065289	rs369267946	N>S	A:190	(44.74, 58.74, 39.67)
17:40065247		P>R	A:204	(34.33, 56.19, 57.37)
17:40063823	rs368787334	V>M	A:207	(40.39, 63.77, 58.45)
17:40063808		V>I	A:212	(44.05, 60.28, 55.98)
17:40063805		Y>H	A:213	(43.28, 57.85, 59.93)
17:40063789	rs139584437	A>V	A:218	(34.08, 48.99, 49.14)
17:40063783		K>R	A:220	(32.99, 46.08, 42.23)
17:40063781		V>M	A:221	(37.70, 45.02, 40.12)
17:40063769		A>T	A:225	(41.93, 43.45, 33.43)
17:40063766		D>N	A:226	(43.52, 39.73, 34.06)
17:40063759		I>T	A:228	(46.32, 45.03, 31.98)
17:40063747		K>R	A:232	(49.59, 46.80, 39.98)
17:40063733	rs549516701	E>K	A:237	(41.26, 36.39, 46.64)
17:40063727		P>S	A:239	(34.80, 37.36, 47.21)
17:40063697		E>Q	A:249	(30.62, 19.27, 43.57)
17:40062878		D>N	A:257	(35.75, 28.00, 34.16)
17:40062851		L>V	A:266	(27.48, 24.34, 38.60)
17:40062847		T>S	A:267	(24.86, 26.91, 40.76)
17:40062838		N>S	A:270	(17.37, 21.63, 45.41)
17:40062832	COSM1189470	K>R	A:272	(17.60, 16.94, 47.91)
17:40062815		M>V	A:278	(23.83, 19.93, 30.57)
17:40062797		A>S	A:284	(19.50, 29.05, 26.96)
17:40061888		G>D	A:297	(9.54, 24.02, 39.31)
17:40061886		V>I	A:298	(10.93, 26.65, 41.64)
17:40061878		E>D	A:300	(11.89, 19.94, 42.26)
17:40061843		S>N	A:312	(36.13, 19.79, 24.93)
17:40061828		Y>C	A:317	(33.54, 12.68, 30.85)
17:40061808		L>V	A:324	(25.45, 12.31, 36.01)
17:40061782		H>Q	A:332	(12.34, 12.08, 43.62)
17:40061029		I>V	A:340	(20.56, 17.65, 27.43)
17:40061014		A>T	A:345	(25.24, 26.73, 17.34)
17:40058056		R>T	A:359	(33.06, 9.38, 27.73)
17:40058051	rs138293941	I>V	A:361	(25.34, 8.56, 30.11)
17:40058047	rs150458004	R>Q	A:362	(28.63, 4.70, 27.83)
17:40058045		D>N	A:363	(30.72, 5.87, 32.92)
17:40058018		E>K	A:372	(13.40, 6.15, 38.23)
17:40058009	rs188073019	I>V	A:375	(17.50, 11.94, 29.35)
17:40057988		P>T	A:382	(27.78, 22.48, 14.22)
17:40057985		N>D	A:383	(28.23, 18.30, 13.34)
17:40057972		G>V	A:387	(24.71, 13.84, 18.24)
17:40057967	COSM1243060	R>W	A:389	(24.00, 8.97, 15.62)
17:40055030		T>P	A:398	(21.96, 2.06, 28.42)
17:40055027		G>R	A:399	(18.11, 1.64, 28.92)
17:40055024		I>V	A:400	(18.76, 5.22, 29.86)
17:40054959		H>Q	A:421	(2.67, 19.86, 31.50)
17:40054957		R>Q	A:422	(3.91, 18.99, 25.26)
17:40049421		S>N	A:489	(23.83, 54.62, 9.33)
17:40049407		S>G	A:494	(24.43, 45.64, 0.85)
17:40049403	rs387907386	R>H	A:495	(23.62, 42.10, -3.42)
17:40049404	rs141255682	R>C	A:495	(23.62, 42.10, -3.42)
17:40049391		A>V	A:499	(34.96, 43.53, 3.96)
17:40049392		A>T	A:499	(34.96, 43.53, 3.96)
17:40049386	rs151030814	V>M	A:501	(38.81, 40.36, 8.00)
17:40049368		R>W	A:507	(35.86, 27.78, 10.23)
17:40049353		M>V	A:512	(31.49, 35.37, 4.89)
17:40049322	rs375851714	D>G	A:522	(27.33, 39.50, -8.14)
17:40049320	rs34533754	E>K	A:523	(31.50, 40.73, -6.27)
17:40049311		V>L	A:526	(35.80, 39.27, 1.91)
17:40049307		A>V	A:527	(38.32, 42.04, -0.07)
17:40048654		I>V	A:550	(41.59, 36.96, -0.27)
17:40048611		P>L	A:564	(38.46, 52.10, -1.56)
17:40048566		Y>C	A:579	(41.66, 49.99, 22.62)
17:40048561		S>G	A:581	(42.53, 47.41, 16.20)
17:40048553	rs374364035	M>I	A:583	(40.87, 53.21, 18.36)
17:40048555		M>V	A:583	(40.87, 53.21, 18.36)
17:40048548		T>I	A:585	(39.78, 51.08, 12.11)
17:40048545		M>T	A:586	(37.75, 54.47, 14.30)
17:40048542	rs549245272	N>S	A:587	(42.05, 56.60, 12.16)
17:40048536		A>V	A:589	(36.32, 57.14, 7.03)
17:40043952	rs147387411	R>Q	A:592	(31.10, 54.60, 8.46)
17:40043953		R>W	A:592	(31.10, 54.60, 8.46)
17:40043940		I>T	A:596	(34.14, 44.08, 18.12)
17:40043938		I>V	A:597	(34.23, 39.17, 17.66)
17:40043917		A>S	A:604	(37.19, 51.33, 30.14)
17:40043913		L>P	A:605	(39.21, 50.00, 27.04)
17:40043904		K>R	A:608	(38.27, 55.03, 25.76)
17:40043902		L>M	A:609	(36.06, 51.93, 21.52)
17:40043889	rs142738500	A>V	A:613	(32.34, 56.12, 17.32)
17:40043887		D>Y	A:614	(29.69, 58.14, 19.08)
17:40043883		Q>L	A:615	(33.78, 61.54, 18.23)
17:40043877		G>V	A:617	(29.94, 57.74, 12.83)
17:40043874		V>A	A:618	(31.30, 54.52, 13.39)
17:40043866		I>V	A:621	(28.24, 45.30, 15.97)
17:40042550		I>M	A:629	(22.52, 37.81, 9.31)
17:40042547		K>N	A:630	(21.12, 41.82, 5.46)
17:40042531		I>V	A:636	(29.12, 39.11, 10.79)
17:40042497		L>P	A:647	(20.08, 26.22, 3.49)
17:40042487		K>N	A:650	(14.59, 29.78, 4.30)
17:40042479		R>H	A:653	(14.94, 34.06, 1.76)
17:40042480		R>C	A:653	(14.94, 34.06, 1.76)
17:40042476		P>L	A:654	(15.23, 38.29, 1.98)
17:40042468		V>M	A:657	(11.53, 39.77, 10.39)
17:40042461		Y>C	A:659	(17.18, 39.33, 14.80)
17:40042452		R>H	A:662	(22.06, 41.15, 25.76)
17:40042453		R>C	A:662	(22.06, 41.15, 25.76)
17:40042446		G>A	A:664	(23.99, 34.38, 19.41)
17:40042441		M>V	A:666	(19.03, 32.81, 21.56)
17:40042404		T>M	A:678	(7.88, 34.08, 9.07)
17:40042392	rs148168367	Y>C	A:682	(15.59, 42.79, 5.99)
17:40042377		I>T	A:687	(24.33, 43.89, 21.12)
17:40040522	COSM979367	P>L	A:693	(26.95, 47.92, 24.34)
17:40040519		G>D	A:694	(28.25, 49.85, 20.98)
17:40040511		F>I	A:697	(18.44, 46.13, 22.42)
17:40040507		M>T	A:698	(16.60, 52.17, 20.43)
17:40040483	rs199626711	D>V	A:706	(14.08, 54.17, 9.51)
17:40040477		P>L	A:708	(11.50, 50.19, 4.15)
17:40040456		V>A	A:715	(13.35, 42.52, 20.92)
17:40040454	rs188806283	L>F	A:716	(15.50, 38.53, 23.09)
17:40039484		I>T	A:719	(17.65, 40.63, 33.77)
17:40039478		G>V	A:721	(18.61, 47.42, 32.97)
17:40039476		T>A	A:722	(16.83, 50.59, 31.54)
17:40039467	rs79062040	Y>D	A:725	(11.75, 50.62, 30.49)
17:40039461		I>V	A:727	(11.49, 50.32, 23.02)
17:40039454	rs141297025	R>Q	A:729	(10.96, 56.19, 26.65)
17:40039455		R>W	A:729	(10.96, 56.19, 26.65)
17:40039452		G>R	A:730	(9.02, 55.52, 21.41)
17:40039434		L>F	A:736	(8.81, 53.30, 17.50)
17:40039419	COSM1181597	V>I	A:741	(7.87, 41.17, 19.23)
17:40039400		T>M	A:747	(11.57, 35.63, 34.60)
17:40039388		M>T	A:751	(13.46, 33.13, 42.38)
17:40035141		A>S	A:768	(13.03, 46.54, 40.08)
17:40035131		T>I	A:771	(13.23, 42.98, 36.48)
17:40035126		V>I	A:773	(8.87, 40.72, 35.23)
17:40035114		Q>E	A:777	(3.62, 44.04, 32.45)
17:40035104	rs200877438	K>R	A:780	(1.67, 43.62, 27.78)
17:40035080		R>Q	A:788	(1.31, 33.36, 28.55)
17:40035081		R>W	A:788	(1.31, 33.36, 28.55)
17:40035070		D>E	A:791	(6.94, 28.03, 25.01)
17:40035058		E>D	A:795	(2.40, 30.95, 19.60)
17:40035056		I>S	A:796	(3.28, 36.37, 19.31)
17:40034430		V>M	A:805	(-0.24, 38.89, 5.43)
17:40034427		A>T	A:806	(-4.02, 40.28, 5.98)
17:40034424		N>D	A:807	(-3.53, 43.89, 6.94)

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
17:40070098	COSM186918	T>M	A:10	(42.11, 43.17, 48.90)
17:40069998	COSM73554	L>F	A:43	(48.22, 36.77, 64.90)
17:40061813	COSM3421566	T>N	A:322	(29.76, 16.47, 38.11)
17:40060993	COSM3717364	A>T	A:352	(32.11, 16.60, 20.46)
17:40057984	COSM1679812	N>S	A:383	(28.23, 18.30, 13.34)
17:40042447	COSM1383268	G>R	A:664	(23.99, 34.38, 19.41)
17:40035093	COSM3188014	V>L	A:784	(4.80, 45.63, 22.97)

3PFF.A | ACLY.

3PFF.A | ACLY

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants