3FEY.C | KPNA2

General Structure Information

PDB ID	3fey
HGNC Gene Label(s)	KPNA2
Structure Name	crystal structure of the cbc-importin alpha complex.
Resolution	2.2Å
Reference	AUTH S.M.DIAS,K.F.WILSON,K.S.ROJAS,A.L.AMBROSIO,R.A.CERIONETITL THE MOLECULAR BASIS FOR THE REGULATION OF THE CAP-BINDINGTITL 2 COMPLEX BY THE IMPORTINS.REF NAT.STRUCT.MOL.BIOL. V. 16 930 2009REFN ISSN 1545-9993PMID 19668212DOI 10.1038/NSMB.1649

Variant Set Distributions

ExAC Variants

Number Of Residues	427
Number Of SNVs	105
Number Of Permutations	66052
Optimal Distance Threshold	28.0
K Statistic	0.368
p-value	0.048

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
17:66033606		N>H	C:70	(15.90, 8.38, 4.35)
17:66033607		N>S	C:70	(15.90, 8.38, 4.35)
17:66033609		Q>K	C:71	(11.65, 10.97, 7.06)
17:66036812	COSM3958681	V>L	C:78	(17.38, -2.12, -1.63)
17:66036813		V>A	C:78	(17.38, -2.12, -1.63)
17:66036818		D>Y	C:80	(20.01, 2.11, 2.34)
17:66036835		I>M	C:85	(20.46, -5.83, 7.10)
17:66036837	rs142064368	N>S	C:86	(24.92, -6.38, 6.17)
17:66036843		S>N	C:88	(27.37, -4.67, 13.53)
17:66036845	COSM1256048	N>H	C:89	(25.23, -1.69, 14.88)
17:66036860		L>I	C:94	(15.45, -2.85, 14.02)
17:66036870		T>I	C:97	(14.17, -4.98, 8.99)
17:66036876		A>G	C:99	(12.36, -0.65, 5.79)
17:66036878		A>S	C:100	(11.62, -3.73, 4.32)
17:66038223		Q>K	C:109	(3.76, -2.28, -7.66)
17:66038241		I>V	C:115	(13.81, -7.75, -1.19)
17:66038246		I>M	C:116	(14.25, -12.31, -3.10)
17:66038247	rs144637470	R>W	C:117	(16.51, -10.00, -7.40)
17:66038248	rs148032855	R>Q	C:117	(16.51, -10.00, -7.40)
17:66038250		A>T	C:118	(19.34, -8.91, -2.21)
17:66038259		I>V	C:121	(15.34, -14.54, 2.73)
17:66038263		P>L	C:122	(18.86, -15.39, 4.64)
17:66038266		K>R	C:123	(20.49, -11.86, 7.38)
17:66038271		V>M	C:125	(15.63, -16.51, 8.65)
17:66038275		S>F	C:126	(18.60, -14.98, 11.24)
17:66038298		S>G	C:134	(11.40, -8.51, 20.16)
17:66038301		P>S	C:135	(11.74, -5.80, 18.05)
17:66038305		I>T	C:136	(14.40, -7.79, 14.59)
17:66038317		S>C	C:140	(11.36, -10.49, 9.88)
17:66038326		A>V	C:143	(8.61, -9.56, 5.76)
17:66038332		T>S	C:145	(4.43, -12.70, 5.73)
17:66038341		A>D	C:148	(4.91, -15.57, 1.08)
17:66038350		T>I	C:151	(4.29, -15.90, -6.36)
17:66038361		T>A	C:155	(6.58, -18.91, -1.05)
17:66038383		G>V	C:162	(14.15, -22.00, 6.59)
17:66038392	rs11545989	P>R	C:165	(11.66, -24.39, 10.80)
17:66038400		I>V	C:168	(7.21, -23.73, 14.12)
17:66038401		I>T	C:168	(7.21, -23.73, 14.12)
17:66038422		H>R	C:175	(6.67, -11.42, 22.85)
17:66038425		A>V	C:176	(1.53, -12.32, 20.92)
17:66038445		V>I	C:183	(0.28, -17.96, 12.45)
17:66038463		I>V	C:189	(3.99, -21.07, 3.51)
17:66039065	COSM1521934	V>L	C:206	(-0.25, -29.10, 14.16)
17:66039078		L>S	C:210	(-3.85, -27.06, 17.99)
17:66039081		A>V	C:211	(-1.69, -25.07, 21.67)
17:66039228	COSM1385448	R>C	C:227	(-10.53, -12.96, 13.25)
17:66039246		L>F	C:233	(-6.01, -24.42, 11.09)
17:66039250		S>C	C:234	(-8.03, -23.38, 6.79)
17:66039253		N>S	C:235	(-4.77, -23.05, 4.54)
17:66039256		L>R	C:236	(-3.23, -26.94, 7.43)
17:66039264		N>D	C:239	(-5.69, -27.87, -1.26)
17:66039282		P>A	C:245	(-2.37, -35.63, 6.24)
17:66039283		P>L	C:245	(-2.37, -35.63, 6.24)
17:66039289		D>G	C:247	(-2.74, -38.09, 10.72)
17:66039294		V>I	C:249	(-7.49, -34.12, 9.89)
17:66039312	rs140011802	T>S	C:255	(-10.06, -27.28, 17.23)
17:66039313	rs141613156	T>I	C:255	(-10.06, -27.28, 17.23)
17:66039322	COSM983374	R>P	C:258	(-13.34, -25.53, 20.60)
17:66039334		H>R	C:262	(-16.43, -18.27, 18.78)
17:66039337		D>A	C:263	(-19.38, -15.95, 19.21)
17:66039342		P>S	C:265	(-18.33, -13.56, 12.45)
17:66039343		P>L	C:265	(-18.33, -13.56, 12.45)
17:66039348		V>I	C:267	(-13.91, -17.59, 13.29)
17:66039358		D>G	C:270	(-12.49, -19.07, 7.99)
17:66039403		R>Q	C:285	(-10.76, -37.71, 4.03)
17:66039411		M>L	C:288	(-13.10, -37.97, 9.53)
17:66039417		V>M	C:290	(-20.04, -37.09, 10.16)
17:66039424		T>R	C:292	(-17.47, -34.79, 14.87)
17:66039436	rs148427582	P>H	C:296	(-26.07, -30.31, 13.65)
17:66039445		V>A	C:299	(-27.75, -27.10, 9.65)
17:66039469		L>W	C:307	(-23.48, -14.53, 2.45)
17:66039955		T>I	C:311	(-21.35, -19.94, 1.24)
17:66039988		T>I	C:322	(-21.38, -36.43, -2.10)
17:66040024		A>G	C:334	(-30.10, -31.95, 11.24)
17:66040060		N>T	C:346	(-31.32, -16.63, -1.57)
17:66040090	rs138064111	T>M	C:356	(-30.29, -27.06, -6.38)
17:66040109		I>M	C:362	(-30.73, -35.38, -1.23)
17:66040119		R>C	C:366	(-32.44, -44.22, 1.44)
17:66040120	COSM3820342	R>H	C:366	(-32.44, -44.22, 1.44)
17:66040122	COSM707522	Q>E	C:367	(-37.61, -45.06, -2.29)
17:66040134		Q>E	C:371	(-41.36, -39.43, 1.03)
17:66040140	rs147590540	V>L	C:373	(-37.88, -34.15, -0.15)
17:66040141	rs140456943	V>D	C:373	(-37.88, -34.15, -0.15)
17:66040150		H>R	C:376	(-40.04, -31.63, 4.73)
17:66040161		P>S	C:380	(-42.89, -27.30, -5.14)
17:66040162		P>L	C:380	(-42.89, -27.30, -5.14)
17:66040182		S>A	C:387	(-39.28, -22.55, -14.26)
17:66040445		F>L	C:391	(-28.99, -22.98, -18.04)
17:66040473	COSM4068951	V>M	C:401	(-35.93, -34.12, -11.52)
17:66040482		Y>H	C:404	(-38.04, -37.70, -7.44)
17:66040498		T>I	C:409	(-41.92, -44.53, -5.83)
17:66040504		E>A	C:411	(-46.25, -43.68, -5.58)
17:66040516		Y>F	C:415	(-46.00, -34.86, -5.51)
17:66040524		H>D	C:418	(-49.85, -32.66, -8.77)
17:66040525	rs140410852	H>R	C:418	(-49.85, -32.66, -8.77)
17:66040543		P>L	C:424	(-40.79, -27.08, -16.97)
17:66040551		N>Y	C:427	(-39.51, -25.54, -21.92)
17:66040552		N>T	C:427	(-39.51, -25.54, -21.92)
17:66040563		A>T	C:431	(-30.53, -26.41, -24.63)
17:66040587		V>F	C:439	(-30.53, -35.67, -18.20)
17:66040608		N>D	C:446	(-37.25, -42.41, -15.63)
17:66041904		G>D	C:455	(-51.58, -47.35, -17.49)
17:66041912		E>Q	C:458	(-51.71, -43.42, -23.91)
17:66041915		K>E	C:459	(-52.88, -39.44, -19.20)
17:66041922	COSM1212745	S>T	C:461	(-48.17, -38.93, -24.34)
17:66041924	rs148952966	I>L	C:462	(-51.52, -36.58, -24.46)
17:66041927		M>V	C:463	(-49.39, -34.67, -20.37)
17:66041954		K>E	C:472	(-39.54, -29.43, -28.05)
17:66041963		A>T	C:475	(-36.41, -31.87, -33.32)
17:66041976		H>R	C:479	(-28.93, -32.55, -32.02)
17:66041982		N>S	C:481	(-25.41, -35.68, -30.39)
17:66041996		K>E	C:486	(-29.75, -43.25, -30.96)
17:66041999		A>T	C:487	(-32.87, -40.92, -27.22)
17:66042003		S>L	C:488	(-35.16, -38.99, -29.38)
17:66042009		S>N	C:490	(-36.40, -44.39, -28.18)
17:66042022		K>N	C:494	(-40.71, -47.05, -26.50)
17:66042032		V>L	C:498	(-50.23, -45.04, -32.41)