General Structure Information
| PDB ID | 1nst |
| HGNC Gene Label(s) | NDST1 |
| Structure Name | the sulfotransferase domain of human haparin sulfate n- deacetylase/n-sulfotransferase |
| Resolution | 2.3Å |
| Reference | AUTH Y.KAKUTA,T.SUEYOSHI,M.NEGISHI,L.C.PEDERSENTITL CRYSTAL STRUCTURE OF THE SULFOTRANSFERASE DOMAINTITL 2 OF HUMAN HEPARAN SULFATE N-DEACETYLASE/TITL 3 N-SULFOTRANSFERASE 1.REF J.BIOL.CHEM. V. 274 10673 1999REFN ISSN 0021-9258PMID 10196134DOI 10.1074/JBC.274.16.10673 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 282 |
| Number Of SNVs | 67 |
| Number Of Permutations | 8510 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.02 |
| p-value | 0.235 |
ClinVar
| Number Of Residues | 282 |
| Number Of SNVs | 4 |
| Number Of Permutations | 326 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.5 |
| p-value | 0.029 |
COSMIC
| Number Of Residues | 282 |
| Number Of SNVs | 6 |
| Number Of Permutations | 688 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.067 |
| p-value | 0.96 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 67 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.434 |
| p-value | 0.038 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 67 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | -0.084 |
| p-value | 0.9 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
