General Structure Information
| PDB ID | 4ja8 |
| HGNC Gene Label(s) | IDH2 |
| Structure Name | complex of mitochondrial isocitrate dehydrogenase r140q mutant with agi-6780 inhibitor |
| Resolution | 1.55Å |
| Reference | AUTH F.WANG,J.TRAVINS,B.DELABARRE,V.PENARD-LACRONIQUE,S.SCHALM,AUTH 2 E.HANSEN,K.STRALEY,A.KERNYTSKY,W.LIU,C.GLISER,H.YANG,AUTH 3 S.GROSS,E.ARTIN,V.SAADA,E.MYLONAS,C.QUIVORON,AUTH 4 J.POPOVICI-MULLER,J.O.SAUNDERS,F.G.SALITURO,S.YAN,S.MURRAY,AUTH 5 W.WEI,Y.GAO,L.DANG,M.DORSCH,S.AGRESTA,D.P.SCHENKEIN,AUTH 6 S.A.BILLER,S.M.SU,S.DE BOTTON,K.E.YENTITL TARGETED INHIBITION OF MUTANT IDH2 IN LEUKEMIA CELLS INDUCESTITL 2 CELLULAR DIFFERENTIATION.REF SCIENCE V. 340 622 2013REFN ISSN 0036-8075PMID 23558173DOI 10.1126/SCIENCE.1234769 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 406 |
| Number Of SNVs | 88 |
| Number Of Permutations | 20505 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.317 |
| p-value | 0.338 |
COSMIC
| Number Of Residues | 406 |
| Number Of SNVs | 10 |
| Number Of Permutations | 1849 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.111 |
| p-value | 0.07 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 88 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.161 |
| p-value | 0.309 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
