General Structure Information
| PDB ID | 1z57 |
| HGNC Gene Label(s) | CLK1 |
| Structure Name | crystal structure of human clk1 in complex with 10z-hymenialdisine |
| Resolution | 1.7Å |
| Reference | AUTH A.N.BULLOCK,S.DAS,J.E.DEBRECZENI,P.RELLOS,O.FEDOROV,AUTH 2 F.H.NIESEN,K.GUO,E.PAPAGRIGORIOU,A.L.AMOS,S.CHO,B.E.TURK,AUTH 3 G.GHOSH,S.KNAPPTITL KINASE DOMAIN INSERTIONS DEFINE DISTINCT ROLES OF CLKTITL 2 KINASES IN SR PROTEIN PHOSPHORYLATION.REF STRUCTURE V. 17 352 2009REFN ISSN 0969-2126PMID 19278650DOI 10.1016/J.STR.2008.12.023 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 331 |
| Number Of SNVs | 69 |
| Number Of Permutations | 34726 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.026 |
| p-value | 0.411 |
COSMIC
| Number Of Residues | 331 |
| Number Of SNVs | 3 |
| Number Of Permutations | 103 |
| Optimal Distance Threshold | 35.0 |
| K Statistic | 0.333 |
| p-value | 0.417 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 69 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 31.0 |
| K Statistic | -0.64 |
| p-value | 0.079 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
