General Structure Information
| PDB ID | 1zbq |
| HGNC Gene Label(s) | HSD17B4 |
| Structure Name | crystal structure of human 17-beta-hydroxysteroid dehydrogenase type 4 in complex with nad |
| Resolution | 2.71Å |
| Reference | AUTH P.LUKACIK,N.SHAFQAT,K.KAVANAGH,J.BRAY,F.VON DELFT,A.EDWARDS,AUTH 2 C.ARROWSMITH,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN 17-BETA-HYDROXYSTEROIDTITL 2 DEHYDROGENASE TYPE 4 IN COMPLEX WITH NADREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 302 |
| Number Of SNVs | 77 |
| Number Of Permutations | 56773 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.145 |
| p-value | 0.79 |
ClinVar
| Number Of Residues | 302 |
| Number Of SNVs | 7 |
| Number Of Permutations | 4493 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.333 |
| p-value | 0.467 |
COSMIC
| Number Of Residues | 302 |
| Number Of SNVs | 4 |
| Number Of Permutations | 103 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.167 |
| p-value | 0.106 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 77 |
| Number Of ClinVar SNVs | 7 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.033 |
| p-value | 0.525 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 77 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.162 |
| p-value | 0.076 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
