1RQD.B | DHPS – ASTRID

1RQD.B | DHPS

General Structure Information

PDB ID	1rqd
HGNC Gene Label(s)	DHPS
Structure Name	deoxyhypusine synthase holoenzyme in its low ionic strength, high ph crystal form with the inhibitor gc7 bound in the active site
Resolution	3.0Å
Reference	AUTH T.C.UMLAND,E.C.WOLFF,M.-H.PARK,D.R.DAVIESTITL A NEW CRYSTAL STRUCTURE OF DEOXYHYPUSINE SYNTHASE REVEALSTITL 2 THE CONFIGURATION OF THE ACTIVE ENZYME AND OF ANTITL 3 ENZYME-NAD-INHIBITOR TERNARY COMPLEXREF J.BIOL.CHEM. V. 279 28697 2004REFN ISSN 0021-9258PMID 15100216DOI 10.1074/JBC.M404095200

Variant Set Distributions

ExAC Variants

Number Of Residues	321
Number Of SNVs	94
Number Of Permutations	57032
Optimal Distance Threshold	9.0
K Statistic	0.046
p-value	0.231

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
19:12792499		S>G	B:28	(16.75, 20.01, 28.57)
19:12792441	rs373390928	E>V	B:47	(29.96, 24.05, 38.01)
19:12792423		G>D	B:53	(30.58, 15.78, 28.35)
19:12792419		F>L	B:54	(31.62, 13.10, 25.79)
19:12792412		T>A	B:57	(28.90, 14.80, 32.19)
19:12792403		G>R	B:60	(28.98, 15.68, 37.58)
19:12792399		R>H	B:61	(26.02, 11.67, 36.37)
19:12792390	rs34610671	Q>R	B:64	(24.93, 15.59, 41.35)
19:12792391	rs376662802	Q>E	B:64	(24.93, 15.59, 41.35)
19:12792381	rs202183750	N>S	B:67	(27.03, 15.74, 47.34)
19:12792375		M>T	B:69	(25.98, 9.87, 49.38)
19:12791136	rs148284175	E>K	B:71	(23.37, 16.18, 52.21)
19:12791132		K>R	B:72	(20.30, 11.08, 53.42)
19:12791067	rs200934098	L>F	B:94	(24.23, 4.45, 62.59)
19:12791052		I>V	B:99	(29.59, 5.82, 52.96)
19:12791039		Y>C	B:103	(40.74, 1.48, 48.44)
19:12791030		N>S	B:106	(46.77, 0.79, 42.32)
19:12791028		L>F	B:107	(44.68, 3.84, 44.01)
19:12791013		I>V	B:112	(44.76, 8.54, 45.77)
19:12791009	rs201592131 COSM991403	R>H	B:113	(48.61, 7.36, 51.57)
19:12791003	rs374386379	T>I	B:115	(42.56, 11.46, 49.01)
19:12790997		R>H	B:117	(45.03, 10.72, 55.26)
19:12790984		Q>H	B:121	(41.64, 12.20, 59.19)
19:12790977		M>V	B:124	(34.04, 11.90, 55.53)
19:12790729		V>A	B:127	(33.15, 0.55, 55.17)
19:12790720		T>I	B:130	(41.38, -2.80, 50.05)
19:12790714		A>V	B:132	(46.55, -6.47, 50.00)
19:12790709		G>S	B:134	(46.31, -1.44, 50.07)
19:12790706		V>M	B:135	(46.68, -2.77, 53.43)
19:12790678	COSM1304036	A>V	B:144	(59.24, 4.34, 52.94)
19:12790673		T>P	B:146	(56.82, 5.45, 46.52)
19:12790661	COSM709942 COSM991402	E>K	B:150	(59.41, 6.08, 33.08)
19:12790652		L>I	B:153	(61.49, 1.61, 33.17)
19:12790649		R>G	B:154	(62.44, -3.05, 30.04)
19:12790646		G>R	B:155	(62.93, -5.26, 34.58)
19:12790642	rs142480793	K>R	B:156	(67.39, -6.89, 33.11)
19:12790637		L>F	B:158	(64.35, -2.12, 37.42)
19:12790633	rs139871951	R>Q	B:159	(65.39, -8.13, 40.21)
19:12790625		G>R	B:162	(66.28, -3.13, 43.55)
19:12790619	rs151125642	N>D	B:164	(60.21, -3.15, 42.74)
19:12790615		R>M	B:165	(57.12, -1.39, 36.82)
19:12790510	COSM4074395	N>S	B:173	(63.80, -4.29, 47.43)
19:12790506	rs10425108	E>D	B:174	(65.61, -1.35, 50.39)
19:12790472		I>V	B:186	(53.27, -7.11, 65.21)
19:12790457	rs138403788	V>L	B:191	(50.41, -16.04, 67.39)
19:12790356		G>D	B:198	(41.43, -16.13, 71.82)
19:12790357		G>S	B:198	(41.43, -16.13, 71.82)
19:12790354		V>I	B:199	(42.35, -13.74, 69.21)
19:12790344		T>M	B:202	(40.09, -11.55, 60.79)
19:12790323		R>Q	B:209	(47.20, -5.02, 66.24)
19:12790324		R>W	B:209	(47.20, -5.02, 66.24)
19:12790309		I>V	B:214	(51.85, 2.36, 61.91)
19:12790291		V>M	B:220	(44.51, 5.06, 55.93)
19:12790279	rs575896014	A>S	B:224	(40.49, 3.54, 60.69)
19:12790273		K>E	B:226	(41.61, 6.93, 66.14)
19:12788189		P>S	B:234	(39.13, -10.99, 51.43)
19:12788185		A>V	B:235	(42.89, -11.63, 49.94)
19:12788186	rs547740533	A>T	B:235	(42.89, -11.63, 49.94)
19:12788180		T>A	B:237	(47.25, -13.69, 51.56)
19:12788174	rs535857791	G>S	B:239	(51.07, -9.93, 49.39)
19:12788170		S>L	B:240	(54.17, -8.42, 51.27)
19:12788159		M>V	B:244	(56.11, -11.05, 55.47)
19:12788131		P>L	B:253	(54.11, -21.68, 63.83)
19:12788128		G>V	B:254	(49.55, -20.71, 63.57)
19:12788123		V>I	B:256	(44.42, -18.36, 61.59)
19:12788114		I>V	B:259	(37.41, -15.38, 55.08)
19:12788111		V>I	B:260	(33.67, -16.53, 57.54)
19:12788007		T>R	B:268	(26.05, -6.81, 59.09)
19:12788004		Q>R	B:269	(28.10, -2.78, 58.29)
19:12788005		Q>E	B:269	(28.10, -2.78, 58.29)
19:12788001		A>V	B:270	(24.46, -3.34, 54.84)
19:12788002		A>T	B:270	(24.46, -3.34, 54.84)
19:12787981		G>R	B:277	(26.94, 4.11, 49.62)
19:12787976		M>I	B:278	(28.33, 2.03, 46.43)
19:12787965		G>V	B:282	(37.68, 0.13, 40.62)
19:12787960		G>S	B:284	(37.16, -6.53, 41.49)
19:12787957		V>M	B:285	(37.38, -8.04, 45.16)
19:12787953		V>A	B:286	(36.96, -3.82, 45.85)
19:12787945	rs368781559	H>D	B:289	(33.14, -7.90, 49.11)
19:12787933		A>T	B:293	(26.79, -6.37, 50.63)
19:12787929	rs149307460	N>S	B:294	(24.83, -3.34, 49.33)
19:12786955		R>Q	B:297	(20.09, -2.47, 51.85)
19:12786956		R>W	B:297	(20.09, -2.47, 51.85)
19:12786950		G>R	B:299	(20.53, -2.33, 47.68)
19:12786946		A>V	B:300	(22.19, 0.71, 46.98)
19:12786932	rs200308259	Y>H	B:305	(30.70, 2.30, 40.11)
19:12786929		I>V	B:306	(35.99, 5.93, 39.44)
19:12786889		A>D	B:319	(30.28, -3.79, 34.78)
19:12786878	COSM991399	E>K	B:323	(25.23, -6.14, 35.50)
19:12786866		W>R	B:327	(23.13, -10.30, 39.94)
19:12786853	rs138578372	R>Q	B:331	(17.27, 0.71, 45.92)
19:12786854	rs376086846	R>W	B:331	(17.27, 0.71, 45.92)
19:12786851		V>L	B:332	(15.51, -0.12, 40.57)
19:12786846		D>E	B:333	(15.11, 3.50, 42.94)
19:12786848		D>N	B:333	(15.11, 3.50, 42.94)
19:12786845		A>S	B:334	(18.87, 4.34, 41.64)
19:12786836	rs202112377	V>I	B:337	(27.43, 7.32, 38.11)
19:12786747		V>I	B:339	(33.65, 7.84, 35.63)
19:12786740	rs137888580	A>G	B:341	(38.67, 7.01, 34.52)
19:12786741	rs532677547	A>T	B:341	(38.67, 7.01, 34.52)
19:12786738	COSM1523927	D>H	B:342	(42.89, 7.24, 36.31)
19:12786734	rs61730841	A>G	B:343	(41.34, 7.81, 39.89)
19:12786735	rs200920073	A>T	B:343	(41.34, 7.81, 39.89)
19:12786686		M>T	B:359	(35.87, 19.67, 56.83)
19:12786680		A>D	B:361	(29.90, 18.94, 59.11)
19:12786681		A>T	B:361	(29.90, 18.94, 59.11)