General Structure Information
| PDB ID | 2ybx |
| HGNC Gene Label(s) | PIP4K2A |
| Structure Name | crystal structure of human phosphatidylinositol-5-phosphate 4-kinase type-2 alpha |
| Resolution | 2.56Å |
| Reference | AUTH L.TRESAUGUES,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,T.EKBLAD,S.FLODIN,S.GRASLUND,AUTH 3 T.KARLBERG,T.KOTENYOVA,E.KOUZNETSOVA,T.NYMAN,C.PERSSON,AUTH 4 H.SCHULER,M.I.SIPONEN,A.G.THORSELL,E.WAHLBERG,J.WEIGELT,AUTH 5 P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN PHOSPHATIDYLINOSITOL-5-TITL 2 PHOSPHATE 4-KINASE TYPE-2 ALPHAREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 314 |
| Number Of SNVs | 69 |
| Number Of Permutations | 13140 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.197 |
| p-value | 0.179 |
COSMIC
| Number Of Residues | 314 |
| Number Of SNVs | 5 |
| Number Of Permutations | 266 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.2 |
| p-value | 0.481 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 69 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.158 |
| p-value | 0.849 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
