General Structure Information
| PDB ID | 4f7s |
| HGNC Gene Label(s) | CDK8 |
| Structure Name | crystal structure of human cdk8/cycc in the dmg-in conformation |
| Resolution | 2.2Å |
| Reference | AUTH E.V.SCHNEIDER,J.BOTTCHER,R.HUBER,K.MASKOS,L.NEUMANNTITL STRUCTURE-KINETIC RELATIONSHIP STUDY OF CDK8/CYCC SPECIFICTITL 2 COMPOUNDS.REF PROC.NATL.ACAD.SCI.USA V. 110 8081 2013REFN ISSN 0027-8424PMID 23630251DOI 10.1073/PNAS.1305378110 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 339 |
| Number Of SNVs | 25 |
| Number Of Permutations | 20890 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.017 |
| p-value | 0.501 |
COSMIC
| Number Of Residues | 339 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1448 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.1 |
| p-value | 0.694 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 25 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | -0.237 |
| p-value | 0.877 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
