General Structure Information
| PDB ID | 3e0j |
| HGNC Gene Label(s) | POLD2 |
| Structure Name | x-ray structure of the complex of regulatory subunits of human dna polymerase delta |
| Resolution | 3.0Å |
| Reference | AUTH A.G.BARANOVSKIY,N.D.BABAYEVA,V.G.LISTON,AUTH 2 I.B.ROGOZIN,E.V.KOONIN,Y.I.PAVLOV,D.G.VASSYLYEV,AUTH 3 T.H.TAHIROVTITL X-RAY STRUCTURE OF THE COMPLEX OF REGULATORYTITL 2 SUBUNITS OF HUMAN DNA POLYMERASE DELTA.REF CELL CYCLE V. 7 3026 2008REFN ISSN 1538-4101PMID 18818516 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 404 |
| Number Of SNVs | 95 |
| Number Of Permutations | 28095 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.481 |
| p-value | 0.452 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 7:44161638 | rs148158174 | Q>H | E:5 | (40.36, 196.50, 55.66) |
| 7:44161609 | S>F | E:15 | (46.76, 174.50, 49.78) | |
| 7:44161576 | R>Q | E:26 | (27.35, 191.28, 49.57) | |
| 7:44161577 | R>W | E:26 | (27.35, 191.28, 49.57) | |
| 7:44161540 | P>L | E:38 | (15.44, 216.18, 40.97) | |
| 7:44161538 | F>V | E:39 | (18.34, 215.10, 38.36) | |
| 7:44161531 | L>P | E:41 | (12.45, 215.46, 33.12) | |
| 7:44161490 | rs75489188 | A>P | E:55 | (17.22, 234.31, 35.39) |
| 7:44161483 | R>H | E:57 | (21.06, 229.72, 36.48) | |
| 7:44161484 | R>C | E:57 | (21.06, 229.72, 36.48) | |
| 7:44161450 | R>Q | E:68 | (28.74, 233.29, 50.76) | |
| 7:44161448 | COSM453101 COSM453100 |
A>T | E:69 | (29.14, 239.28, 49.74) |
| 7:44161437 | H>Q | E:72 | (33.98, 237.78, 51.05) | |
| 7:44157657 | G>A | E:76 | (28.66, 246.92, 52.69) | |
| 7:44157658 | G>R | E:76 | (28.66, 246.92, 52.69) | |
| 7:44157597 | T>I | E:96 | (25.25, 235.78, 34.47) | |
| 7:44157305 | I>V | E:127 | (40.19, 229.07, 25.22) | |
| 7:44157290 | rs56320764 | E>K | E:132 | (35.69, 240.31, 26.47) |
| 7:44157262 | rs568816628 | R>H | E:141 | (24.40, 242.20, 28.23) |
| 7:44157263 | rs372336011 | R>C | E:141 | (24.40, 242.20, 28.23) |
| 7:44157256 | K>T | E:143 | (32.00, 244.70, 28.84) | |
| 7:44157244 | T>I | E:147 | (41.22, 241.64, 38.55) | |
| 7:44157236 | V>M | E:150 | (38.58, 234.60, 31.50) | |
| 7:44156828 | F>S | E:162 | (33.65, 245.21, 44.60) | |
| 7:44156811 | rs147202391 | D>H | E:168 | (34.89, 252.44, 29.00) |
| 7:44156808 | G>R | E:169 | (31.20, 251.45, 30.55) | |
| 7:44156796 | V>L | E:173 | (36.52, 243.94, 38.88) | |
| 7:44156790 | D>Y | E:175 | (36.83, 241.02, 44.78) | |
| 7:44156786 | Y>C | E:176 | (36.14, 237.35, 41.57) | |
| 7:44156773 | D>E | E:180 | (30.97, 227.77, 48.05) | |
| 7:44156768 | A>V | E:182 | (25.70, 224.13, 50.69) | |
| 7:44156760 | K>Q | E:185 | (22.89, 217.66, 57.37) | |
| 7:44156757 | P>A | E:186 | (26.81, 215.44, 59.22) | |
| 7:44156753 | rs374486246 | A>V | E:187 | (27.18, 211.47, 57.92) |
| 7:44156754 | A>T | E:187 | (27.18, 211.47, 57.92) | |
| 7:44156751 | P>T | E:188 | (25.67, 208.89, 59.50) | |
| 7:44156748 | P>A | E:189 | (27.93, 206.95, 62.24) | |
| 7:44156738 | T>I | E:192 | (31.20, 198.25, 59.50) | |
| 7:44156603 | L>P | E:198 | (32.87, 204.31, 41.60) | |
| 7:44156601 | V>L | E:199 | (33.17, 202.10, 37.23) | |
| 7:44156595 | COSM252729 | G>S | E:201 | (34.19, 203.22, 30.50) |
| 7:44156589 | G>S | E:203 | (33.65, 200.37, 26.20) | |
| 7:44156585 | L>P | E:204 | (31.65, 197.56, 25.36) | |
| 7:44156577 | G>S | E:207 | (40.08, 197.93, 22.29) | |
| 7:44156574 | G>R | E:208 | (40.66, 194.99, 22.94) | |
| 7:44156568 | rs568159170 COSM3778445 COSM3778446 |
E>K | E:210 | (43.94, 193.76, 27.88) |
| 7:44156555 | G>D | E:214 | (39.95, 193.34, 33.08) | |
| 7:44156553 | rs200723893 | T>A | E:215 | (36.41, 193.89, 32.51) |
| 7:44156522 | Q>L | E:225 | (34.39, 184.45, 41.26) | |
| 7:44156514 | D>N | E:228 | (42.06, 184.58, 49.40) | |
| 7:44156508 | G>R | E:230 | (40.18, 188.69, 52.06) | |
| 7:44156493 | A>T | E:235 | (34.22, 192.53, 48.57) | |
| 7:44156490 | A>T | E:236 | (31.65, 191.56, 50.62) | |
| 7:44156484 | rs149552381 | V>I | E:238 | (30.86, 196.10, 48.30) |
| 7:44156477 | rs374534297 | R>Q | E:240 | (24.93, 200.23, 45.79) |
| 7:44156475 | rs570426911 | V>I | E:241 | (28.16, 199.09, 41.75) |
| 7:44156465 | A>V | E:244 | (29.40, 206.28, 34.86) | |
| 7:44156466 | rs138149859 | A>T | E:244 | (29.40, 206.28, 34.86) |
| 7:44156462 | G>D | E:245 | (28.96, 205.75, 31.61) | |
| 7:44156458 | N>K | E:246 | (30.64, 205.95, 28.45) | |
| 7:44156456 | rs146393182 | L>H | E:247 | (28.94, 201.40, 29.42) |
| 7:44156457 | L>F | E:247 | (28.94, 201.40, 29.42) | |
| 7:44156073 | V>M | E:273 | (23.86, 194.13, 18.88) | |
| 7:44155867 | S>L | E:289 | (26.30, 189.84, 43.67) | |
| 7:44155859 | V>M | E:292 | (24.12, 197.72, 39.86) | |
| 7:44155853 | V>M | E:294 | (23.28, 201.98, 35.11) | |
| 7:44155837 | rs78388540 | F>S | E:299 | (26.38, 209.23, 21.69) |
| 7:44155825 | rs3087366 | N>S | E:303 | (18.56, 212.49, 26.77) |
| 7:44155783 | rs375200482 COSM1137694 COSM1137695 |
P>L | E:317 | (17.31, 191.41, 28.95) |
| 7:44155774 | T>I | E:320 | (16.20, 193.37, 34.04) | |
| 7:44155762 | T>M | E:324 | (19.83, 194.23, 42.08) | |
| 7:44155741 | P>L | E:331 | (22.52, 213.74, 36.81) | |
| 7:44155726 | I>T | E:336 | (24.82, 204.83, 49.84) | |
| 7:44155467 | V>M | E:349 | (33.71, 218.37, 33.61) | |
| 7:44155451 | rs141051604 | R>Q | E:354 | (35.03, 221.24, 25.22) |
| 7:44155439 | M>T | E:358 | (40.30, 224.71, 34.41) | |
| 7:44155428 | L>V | E:362 | (39.93, 216.90, 40.79) | |
| 7:44155421 | I>N | E:364 | (36.86, 221.31, 36.46) | |
| 7:44155404 | R>W | E:370 | (34.01, 225.65, 46.14) | |
| 7:44155398 | rs147996458 | R>C | E:372 | (25.15, 226.37, 45.45) |
| 7:44155379 | A>V | E:378 | (23.88, 224.42, 30.82) | |
| 7:44154978 | K>E | E:389 | (11.40, 226.62, 35.24) | |
| 7:44154968 | P>R | E:392 | (18.28, 221.26, 38.84) | |
| 7:44154969 | rs374407272 | P>S | E:392 | (18.28, 221.26, 38.84) |
| 7:44154953 | rs370742575 | E>G | E:397 | (21.68, 219.67, 51.17) |
| 7:44154938 | Y>C | E:402 | (30.64, 216.02, 42.95) | |
| 7:44154923 | rs530029438 | T>N | E:407 | (38.41, 211.12, 34.05) |
| 7:44154903 | I>V | E:414 | (38.89, 215.51, 51.15) | |
| 7:44154896 | R>Q | E:416 | (36.34, 221.02, 55.09) | |
| 7:44154897 | rs147781497 | R>G | E:416 | (36.34, 221.02, 55.09) |
| 7:44154536 | D>N | E:420 | (32.50, 223.38, 58.94) | |
| 7:44154494 | T>A | E:434 | (42.44, 202.97, 32.77) | |
| 7:44154487 | T>I | E:436 | (41.06, 202.03, 36.89) | |
| 7:44154478 | L>R | E:439 | (36.96, 201.10, 46.01) | |
| 7:44154476 | V>M | E:440 | (34.59, 204.73, 48.35) | |
| 7:44154466 | rs376080178 | R>H | E:443 | (34.81, 203.23, 58.18) |
| 7:44154467 | R>C | E:443 | (34.81, 203.23, 58.18) | |
| 7:44154460 | rs558704060 | L>P | E:445 | (35.45, 209.43, 53.19) |
| 7:44154448 | P>H | E:449 | (42.77, 203.25, 43.14) | |
| 7:44154446 | I>F | E:450 | (40.99, 198.99, 41.82) | |
| 7:44154442 | S>N | E:451 | (44.24, 198.40, 38.79) | |
| 7:44154436 | S>L | E:453 | (46.40, 193.42, 34.91) | |
| 7:44154433 | G>A | E:454 | (47.53, 191.19, 32.04) | |
| 7:44154428 | rs374486229 | G>R | E:456 | (51.93, 189.87, 27.70) |
| 7:44154420 | rs147647748 | E>D | E:458 | (57.39, 190.68, 27.41) |