General Structure Information
| PDB ID | 4a4l |
| HGNC Gene Label(s) | PLK1 |
| Structure Name | crystal structure of polo-like kinase 1 in complex with a 5-(2-amino-pyrimidin-4-yl)-1h-pyrrole inhibitor |
| Resolution | 2.35Å |
| Reference | AUTH M.CARUSO,B.VALSASINA,D.BALLINARI,J.A.BERTRAND,M.G.BRASCA,AUTH 2 M.CALDARELLI,P.CAPPELLA,F.FIORENTINI,L.M.GIANELLINI,AUTH 3 A.SCOLARO,I.BERIATITL 5-(2-AMINO-PYRIMIDIN-4-YL)-1H-PYRROLE AND 2-(2-AMINO-TITL 2 PYRIMIDIN-4-YL)-1,5,6,7-TETRAHYDRO-PYRROLO[3,2-C]PYRIDIN-4-TITL 3 ONE DERIVATIVES AS NEW CLASSES OF SELECTIVE AND ORALLYTITL 4 AVAILABLE POLO-LIKE KINASE 1 INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 22 96 2012REFN ISSN 0960-894XPMID 22154349DOI 10.1016/J.BMCL.2011.11.065 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 291 |
| Number Of SNVs | 53 |
| Number Of Permutations | 9367 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.216 |
| p-value | 0.133 |
COSMIC
| Number Of Residues | 291 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1298 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.357 |
| p-value | 0.344 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 53 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.325 |
| p-value | 0.231 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
