General Structure Information
| PDB ID | 3nbn |
| HGNC Gene Label(s) | NOTCH1 |
| Structure Name | crystal structure of a dimer of notch transcription complex trimers on hes1 dna |
| Resolution | 3.45Å |
| Reference | AUTH K.L.ARNETT,M.HASS,D.G.MCARTHUR,M.X.ILAGAN,J.C.ASTER,R.KOPAN,AUTH 2 S.C.BLACKLOWTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO COOPERATIVETITL 2 ASSEMBLY OF DIMERIC NOTCH TRANSCRIPTION COMPLEXES.REF NAT.STRUCT.MOL.BIOL. V. 17 1312 2010REFN ISSN 1545-9993PMID 20972443DOI 10.1038/NSMB.1938 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 196 |
| Number Of SNVs | 42 |
| Number Of Permutations | 6851 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.22 |
| p-value | 0.162 |
COSMIC
| Number Of Residues | 196 |
| Number Of SNVs | 6 |
| Number Of Permutations | 3965 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.067 |
| p-value | 0.6 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 42 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | -0.141 |
| p-value | 0.315 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
