General Structure Information
| PDB ID | 3fay |
| HGNC Gene Label(s) | IQGAP1 |
| Structure Name | crystal structure of the gap-related domain of iqgap1 |
| Resolution | 2.2Å |
| Reference | AUTH V.B.KURELLA,J.M.RICHARD,C.L.PARKE,L.F.LECOUR,AUTH 2 H.D.BELLAMY,D.K.WORTHYLAKETITL CRYSTAL STRUCTURE OF THE GTPASE-ACTIVATINGTITL 2 PROTEIN-RELATED DOMAIN FROM IQGAP1.REF J.BIOL.CHEM. V. 284 14857 2009REFN ISSN 0021-9258PMID 19321438DOI 10.1074/JBC.M808974200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 368 |
| Number Of SNVs | 65 |
| Number Of Permutations | 22046 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.36 |
| p-value | 0.337 |
COSMIC
| Number Of Residues | 368 |
| Number Of SNVs | 5 |
| Number Of Permutations | 324 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.1 |
| p-value | 0.826 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 65 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | -0.222 |
| p-value | 0.812 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
