General Structure Information
| PDB ID | 2yho |
| HGNC Gene Label(s) | UBE2D1 |
| Structure Name | the idol-ube2d complex mediates sterol-dependent degradation of the ldl receptor |
| Resolution | 2.1Å |
| Reference | AUTH L.ZHANG,L.FAIRALL,B.T.GOULT,A.C.CALKIN,C.HONG,C.J.MILLARD,AUTH 2 P.TONTONOZ,J.W.SCHWABETITL THE IDOL-UBE2D COMPLEX MEDIATES STEROL-DEPENDENTTITL 2 DEGRADATION OF THE LDL RECEPTOR.REF GENES DEV. V. 25 1262 2011REFN ISSN 0890-9369PMID 21685362DOI 10.1101/GAD.2056211 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 147 |
| Number Of SNVs | 13 |
| Number Of Permutations | 1405 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.115 |
| p-value | 0.506 |
COSMIC
| Number Of Residues | 147 |
| Number Of SNVs | 4 |
| Number Of Permutations | 465 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.667 |
| p-value | 0.447 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 13 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.346 |
| p-value | 0.644 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
