General Structure Information
| PDB ID | 4bkt |
| HGNC Gene Label(s) | VHL |
| Structure Name | von hippel lindau protein:elonginb:elonginc complex, in complex with (2s,4r)-n-methyl-1-[2-(3-methyl-1,2-oxazol-5-yl)ethanoyl]-4- oxidanyl-pyrrolidine-2-carboxamide |
| Resolution | 2.35Å |
| Reference | AUTH D.M.DIAS,I.VAN MOLLE,M.G.J.BAUD,C.GALDEANO,C.F.G.C.GERALDES,AUTH 2 A.CIULLITITL IS NMR FRAGMENT SCREENING FINE-TUNED TO ASSESS DRUGGABILITYTITL 2 OF PROTEIN-PROTEIN INTERACTIONS?REF ACS MED.CHEM.LETT. V. 5 23 2014REFN ISSN 1948-5875PMID 24436777DOI 10.1021/ML400296C |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 143 |
| Number Of SNVs | 39 |
| Number Of Permutations | 22400 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.325 |
| p-value | 0.117 |
ClinVar
| Number Of Residues | 143 |
| Number Of SNVs | 35 |
| Number Of Permutations | 15698 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.173 |
| p-value | 0.005 |
COSMIC
| Number Of Residues | 143 |
| Number Of SNVs | 36 |
| Number Of Permutations | 14904 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.587 |
| p-value | 0.024 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 39 |
| Number Of ClinVar SNVs | 34 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.154 |
| p-value | 0.001 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 39 |
| Number Of COSMIC SNVs | 13 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.246 |
| p-value | 0.016 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
