General Structure Information
| PDB ID | 2zt7 |
| HGNC Gene Label(s) | GARS |
| Structure Name | crystal structure of human glycyl-trna synthetase (glyrs) in complex with glycine and atp |
| Resolution | 2.7Å |
| Reference | AUTH R.T.GUO,Y.E.CHONG,M.GUO,X.L.YANGTITL CRYSTAL STRUCTURES AND BIOCHEMICAL ANALYSES SUGGESTTITL 2 UNIQUE MECHANISM AND ROLE FOR HUMAN GLYRS IN AP4ATITL 3 HOMEOSTASISREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 530 |
| Number Of SNVs | 110 |
| Number Of Permutations | 60879 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.016 |
| p-value | 0.318 |
ClinVar
| Number Of Residues | 530 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1891 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.4 |
| p-value | 0.028 |
COSMIC
| Number Of Residues | 530 |
| Number Of SNVs | 5 |
| Number Of Permutations | 817 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.2 |
| p-value | 0.403 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 110 |
| Number Of ClinVar SNVs | 5 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.318 |
| p-value | 0.038 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 110 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.131 |
| p-value | 0.698 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
