General Structure Information
| PDB ID | 3ua8 |
| HGNC Gene Label(s) | GRIA2 |
| Structure Name | crystal structure analysis of a 6-amino quinazolinedione sulfonamide bound to human glur2 |
| Resolution | 1.9Å |
| Reference | AUTH D.ORAIN,S.OFNER,M.KOLLER,D.A.CARCACHE,W.FROESTL,H.ALLGEIER,AUTH 2 V.RASETTI,J.NOZULAK,H.MATTES,N.SOLDERMANN,P.FLOERSHEIM,AUTH 3 S.DESRAYAUD,J.KALLEN,K.LINGENHOEHL,S.URWYLERTITL 6-AMINO QUINAZOLINEDIONE SULFONAMIDES AS ORALLY ACTIVETITL 2 COMPETITIVE AMPA RECEPTOR ANTAGONISTS.REF BIOORG.MED.CHEM.LETT. V. 22 996 2012REFN ISSN 0960-894XPMID 22197388DOI 10.1016/J.BMCL.2011.12.009 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 257 |
| Number Of SNVs | 19 |
| Number Of Permutations | 2461 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.175 |
| p-value | 0.048 |
COSMIC
| Number Of Residues | 257 |
| Number Of SNVs | 7 |
| Number Of Permutations | 3870 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.048 |
| p-value | 0.295 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 19 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | -0.14 |
| p-value | 0.597 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
