General Structure Information
| PDB ID | 4fu4 |
| HGNC Gene Label(s) | MMP13 |
| Structure Name | human collagenase 3 (mmp-13) with peptide from pro-domain |
| Resolution | 2.85Å |
| Reference | AUTH E.A.STURA,R.VISSE,P.CUNIASSE,V.DIVE,H.NAGASETITL CRYSTAL STRUCTURE OF FULL-LENGTH HUMAN COLLAGENASE 3TITL 2 (MMP-13) WITH PEPTIDES IN THE ACTIVE SITE DEFINES EXOSITESTITL 3 IN THE CATALYTIC DOMAIN.REF FASEB J. V. 27 4395 2013REFN ISSN 0892-6638PMID 23913860DOI 10.1096/FJ.13-233601 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 368 |
| Number Of SNVs | 98 |
| Number Of Permutations | 26959 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.024 |
| p-value | 0.905 |
COSMIC
| Number Of Residues | 368 |
| Number Of SNVs | 12 |
| Number Of Permutations | 14296 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.182 |
| p-value | 0.028 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 98 |
| Number Of COSMIC SNVs | 12 |
| Optimal Distance Threshold | 35.0 |
| K Statistic | -0.122 |
| p-value | 0.263 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
