General Structure Information
| PDB ID | 3alo |
| HGNC Gene Label(s) | MAP2K4 |
| Structure Name | crystal structure of human non-phosphorylated mkk4 kinase domain ternary complex with amp-pnp and p38 peptide |
| Resolution | 2.6Å |
| Reference | AUTH T.MATSUMOTO,T.KINOSHITA,Y.KIRII,K.YOKOTA,K.HAMADA,T.TADATITL CRYSTAL STRUCTURES OF MKK4 KINASE DOMAIN REVEAL THATTITL 2 SUBSTRATE PEPTIDE BINDS TO AN ALLOSTERIC SITE AND INDUCES ANTITL 3 AUTO-INHIBITION STATEREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 400 369 2010REFN ISSN 0006-291XPMID 20732303DOI 10.1016/J.BBRC.2010.08.071 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 289 |
| Number Of SNVs | 23 |
| Number Of Permutations | 10885 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.091 |
| p-value | 0.325 |
COSMIC
| Number Of Residues | 289 |
| Number Of SNVs | 15 |
| Number Of Permutations | 4805 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.038 |
| p-value | 0.541 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 23 |
| Number Of COSMIC SNVs | 14 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.028 |
| p-value | 0.988 |