General Structure Information
| PDB ID | 4cga |
| HGNC Gene Label(s) | CHKA |
| Structure Name | human choline kinase a1 in complex with compound 5 |
| Resolution | 1.74Å |
| Reference | AUTH B.RUBIO-RUIZ,A.FIGUEROLA-CONCHAS,J.RAMOS-TORRECILLAS,AUTH 2 F.CAPITAN-CANADAS,P.RIOS-MARCO,M.P.CARRASCO,M.A.GALLO,AUTH 3 A.ESPINOSA,C.MARCO,C.CONCEPCION,A.ENTRENA-GUADIX,AUTH 4 R.HURTADO-GUERRERO,A.CONEJO-GARCIATITL DISCOVERY OF A NEW BINDING SITE ON HUMAN CHOLINE KINASE A1:TITL 2 DESIGN, SYNTHESIS, CRYSTALLOGRAPHIC STUDIES AND BIOLOGICALTITL 3 EVALUATION OF ASYMMETRICAL BISPYRIDINIUM DERIVATIVESREF J.MED.CHEM. V. 57 507 2014REFN ISSN 0022-2623PMID 24387243DOI 10.1021/JM401665X |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 354 |
| Number Of SNVs | 74 |
| Number Of Permutations | 13638 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.259 |
| p-value | 0.019 |
COSMIC
| Number Of Residues | 354 |
| Number Of SNVs | 3 |
| Number Of Permutations | 160 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.667 |
| p-value | 0.794 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 74 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 34.0 |
| K Statistic | 0.417 |
| p-value | 0.98 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
