General Structure Information
| PDB ID | 2x7o |
| HGNC Gene Label(s) | TGFBR1 |
| Structure Name | crystal structure of tgfbri complexed with an indolinone inhibitor |
| Resolution | 3.7Å |
| Reference | AUTH G.J.ROTH,A.HECKEL,T.BRANDL,M.GRAUERT,S.HOERER,J.T.KLEY,AUTH 2 G.SCHNAPP,P.BAUM,D.MENNERICH,A.SCHNAPP,J.E.PARKTITL DESIGN, SYNTHESIS AND EVALUATION OF INDOLINONES ASTITL 2 INHIBITORS OF THE TRANSFORMING GROWTH FACTOR BETA RECEPTORTITL 3 I (TGFBRI)REF J.MED.CHEM. V. 53 7287 2010REFN ISSN 0022-2623PMID 20919678DOI 10.1021/JM100812A |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 330 |
| Number Of SNVs | 42 |
| Number Of Permutations | 23158 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.028 |
| p-value | 0.277 |
ClinVar
| Number Of Residues | 330 |
| Number Of SNVs | 9 |
| Number Of Permutations | 4670 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.361 |
| p-value | 0.073 |
COSMIC
| Number Of Residues | 330 |
| Number Of SNVs | 11 |
| Number Of Permutations | 1896 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.545 |
| p-value | 0.135 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 42 |
| Number Of ClinVar SNVs | 9 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.165 |
| p-value | 0.237 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 42 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.226 |
| p-value | 0.205 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
