4FL2.A | SYK – ASTRID

4FL2.A | SYK

General Structure Information

PDB ID	4fl2
HGNC Gene Label(s)	SYK
Structure Name	structural and biophysical characterization of the syk activation switch
Resolution	2.19Å
Reference	AUTH U.GRADLER,D.SCHWARZ,V.DRESING,D.MUSIL,J.BOMKE,M.FRECH,AUTH 2 H.GREINER,S.JAKEL,T.RYSIOK,D.MULLER-POMPALLA,A.WEGENERTITL STRUCTURAL AND BIOPHYSICAL CHARACTERIZATION OF THE SYKTITL 2 ACTIVATION SWITCH.REF J.MOL.BIOL. V. 425 309 2013REFN ISSN 0022-2836PMID 23154170DOI 10.1016/J.JMB.2012.11.007

Variant Set Distributions

ExAC Variants

Number Of Residues	555
Number Of SNVs	96
Number Of Permutations	27490
Optimal Distance Threshold	28.0
K Statistic	0.378
p-value	0.652

COSMIC

Number Of Residues	555
Number Of SNVs	11
Number Of Permutations	10405
Optimal Distance Threshold	8.0
K Statistic	0.055
p-value	0.919

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	96
Number Of COSMIC SNVs	11
Optimal Distance Threshold	8.0
K Statistic	0.036
p-value	0.909

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:93606208	rs199606629	A>T	A:10	(-22.42, 9.90, 40.11)
9:93606232		G>S	A:18	(-18.52, 3.59, 36.06)
9:93606236		N>S	A:19	(-16.27, 2.83, 32.11)
9:93606238		I>V	A:20	(-17.77, -1.07, 34.56)
9:93606269		V>G	A:30	(-22.95, -12.43, 41.42)
9:93606277	rs201364101	G>S	A:33	(-26.46, -12.40, 45.32)
9:93606298		L>M	A:40	(-25.14, -1.50, 39.57)
9:93606329		G>V	A:50	(-24.23, 8.46, 30.36)
9:93606343	rs200078199	V>M	A:55	(-31.24, -5.00, 37.60)
9:93606352		G>R	A:58	(-34.36, -14.11, 37.94)
9:93606374	rs149603234	T>I	A:65	(-29.45, 3.04, 28.39)
9:93606379		E>K	A:67	(-30.34, 8.35, 27.02)
9:93606382		R>W	A:68	(-26.62, 14.71, 29.19)
9:93606383		R>Q	A:68	(-26.62, 14.71, 29.19)
9:93606392	rs146786995	N>I	A:71	(-32.13, 19.70, 29.51)
9:93606395	rs200175081 COSM1701305	G>D	A:72	(-29.35, 17.61, 31.43)
9:93606403	rs570398843	A>T	A:75	(-33.85, 9.19, 30.06)
9:93606409		A>T	A:77	(-36.69, 5.05, 26.13)
9:93606412		G>S	A:78	(-37.77, 8.48, 25.80)
9:93606419		R>K	A:80	(-41.00, 9.68, 33.16)
9:93606421		T>A	A:81	(-37.19, 13.64, 32.44)
9:93606422	rs201374653	T>I	A:81	(-37.19, 13.64, 32.44)
9:93606432	rs536147934	S>R	A:84	(-30.52, 12.91, 38.57)
9:93606436	rs201455170	A>T	A:86	(-30.39, 9.71, 41.86)
9:93606439	rs201177148 COSM1267087 COSM1267086	D>N	A:87	(-33.62, 11.90, 41.18)
9:93606448	rs541525343	H>N	A:90	(-34.44, 8.22, 44.52)
9:93606467		S>F	A:96	(-41.55, 0.10, 37.12)
9:93606470	rs200223184	D>V	A:97	(-41.59, 3.25, 34.08)
9:93606482		C>Y	A:101	(-38.19, -4.80, 38.74)
9:93606492		K>N	A:104	(-35.03, -3.74, 46.94)
9:93606508	rs202043759	P>S	A:110	(-16.55, -2.92, 46.73)
9:93606509	rs375028044	P>L	A:110	(-16.55, -2.92, 46.73)
9:93606521		Q>R	A:114	(-12.43, 3.91, 44.21)
9:93606569		E>G	A:130	(-5.20, 10.81, 16.91)
9:93606580		Q>E	A:134	(-1.75, 8.02, 13.19)
9:93606590	rs200097669	N>T	A:137	(-4.96, 9.61, 6.78)
9:93606591		N>K	A:137	(-4.96, 9.61, 6.78)
9:93607737	rs373730562	I>L	A:147	(-14.86, 6.04, 15.55)
9:93607766		K>N	A:156	(-8.81, -4.74, 21.95)
9:93607773		A>T	A:159	(-4.19, -1.43, 24.71)
9:93607774		A>V	A:159	(-4.19, -1.43, 24.71)
9:93607780		T>I	A:161	(0.20, 1.01, 22.23)
9:93607813		K>R	A:172	(15.83, 5.92, 29.99)
9:93624496		A>G	A:196	(12.72, 3.38, 33.35)
9:93624504		N>D	A:199	(16.57, -1.35, 29.23)
9:93624507		N>D	A:200	(15.77, -5.67, 31.42)
9:93624510		G>S	A:201	(11.34, -4.50, 33.09)
9:93624525		C>G	A:206	(5.90, 8.10, 40.62)
9:93624616	rs201857010	T>M	A:236	(0.47, -4.28, 30.13)
9:93626879		E>D	A:242	(-7.31, 0.41, 33.33)
9:93626889		Y>H	A:246	(-10.53, 0.79, 39.41)
9:93626890	rs184127752	Y>C	A:246	(-10.53, 0.79, 39.41)
9:93626914		V>A	A:254	(-6.12, 6.27, 42.98)
9:93626926		P>Q	A:258	(-1.03, 12.29, 33.86)
9:93626940	rs199886319	G>S	A:263	(7.28, 20.08, 26.88)
9:93636959	rs144168552	Q>K	A:337	(-9.00, -10.56, 4.40)
9:93636961		Q>H	A:337	(-9.00, -10.56, 4.40)
9:93636963	rs56071116	R>K	A:338	(-12.40, -14.26, 3.97)
9:93637007	rs200167353 COSM247664 COSM1463523	A>T	A:353	(-10.30, 9.72, -2.23)
9:93637016	rs527917433	E>K	A:356	(-3.30, 11.69, -8.10)
9:93637032		K>R	A:361	(-16.88, 15.59, -15.15)
9:93637037		V>I	A:363	(-23.57, 8.82, -14.29)
9:93637062	rs369986984 COSM1132439	T>M	A:371	(-12.94, -5.90, -18.24)
9:93639854		V>I	A:395	(-5.62, 1.61, -10.06)
9:93639858		V>A	A:396	(-7.09, -1.89, -11.77)
9:93639864		T>N	A:398	(-12.07, -4.88, -8.47)
9:93639905	rs201438493	A>T	A:412	(-40.26, 4.45, -20.90)
9:93639906		A>D	A:412	(-40.26, 4.45, -20.90)
9:93639974		M>V	A:435	(-23.28, 3.57, -8.20)
9:93639983		I>L	A:438	(-24.03, 4.26, -15.60)
9:93639989	rs200202947	E>K	A:440	(-26.16, 3.20, -22.84)
9:93640019		M>L	A:450	(-16.60, -6.38, -5.07)
9:93640040		N>H	A:457	(-28.80, -14.65, 3.54)
9:93640059		N>T	A:463	(-20.63, -19.32, 8.17)
9:93641050	rs532798885	V>I	A:466	(-20.97, -16.15, 13.14)
9:93641063	rs201930376	N>S	A:470	(-20.01, -10.67, 14.14)
9:93641068		I>V	A:472	(-24.83, -6.93, 16.96)
9:93641093		M>T	A:480	(-24.20, 3.36, 10.27)
9:93641094		M>I	A:480	(-24.20, 3.36, 10.27)
9:93641102	rs147125933	K>R	A:483	(-28.25, 7.76, 10.05)
9:93641120		N>S	A:489	(-33.73, 12.56, 1.39)
9:93641168		Q>R	A:505	(-16.89, -12.35, 9.20)
9:93641213		R>H	A:520	(-42.54, 2.17, -12.92)
9:93641220		D>E	A:522	(-43.75, -5.64, -11.51)
9:93641228		Y>C	A:525	(-40.50, -7.56, -7.10)
9:93650059	rs371627100	K>R	A:537	(-42.21, -11.94, 3.64)
9:93650065		Y>C	A:539	(-42.58, -4.59, 1.09)
9:93650067		A>T	A:540	(-44.81, -2.03, 5.45)
9:93650084		N>K	A:545	(-52.19, -1.58, 2.18)
9:93650109		D>Y	A:554	(-36.70, 1.52, 4.75)
9:93650135		M>I	A:562	(-32.62, -7.44, 12.94)
9:93650151		Y>H	A:568	(-27.27, -17.61, 12.25)
9:93650155	COSM753905 COSM1151379	G>V	A:569	(-30.85, -17.08, 6.95)
9:93650821	rs369492720	A>T	A:583	(-53.46, -10.54, 8.27)
9:93650843	COSM3723761 COSM3723760	R>Q	A:590	(-45.86, -8.53, 14.77)
9:93650869		R>G	A:599	(-34.36, -7.83, 26.34)
9:93650875		M>L	A:601	(-31.83, -6.69, 19.51)
9:93650881	rs200438123 COSM48799 COSM3659460 COSM3659459	D>N	A:603	(-37.22, -5.23, 22.30)
9:93650908		D>N	A:612	(-48.29, 4.35, 13.51)
9:93657826	rs200612476	G>R	A:618	(-35.94, 6.25, 12.78)
9:93657832	rs139348511	A>T	A:620	(-31.36, 7.86, 14.18)
9:93657845		L>P	A:624	(-28.37, 5.76, 19.30)
9:93657847		R>W	A:625	(-32.72, 1.50, 21.04)
9:93657848		R>Q	A:625	(-32.72, 1.50, 21.04)
9:93657857	rs150998279	N>S	A:628	(-26.11, 2.35, 23.00)
9:93657871	COSM1228112 COSM1228111	V>M	A:633	(-22.30, -6.46, 24.54)

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:93606256	COSM1625223	E>K	A:26	(-23.44, -9.38, 34.95)
9:93606452	COSM1463519	Y>C	A:91	(-39.97, 7.21, 39.47)
9:93606458	COSM4993462	S>F	A:93	(-37.51, 2.45, 44.11)
9:93637007	COSM247664	A>T	A:353	(-10.30, 9.72, -2.23)
9:93637116	COSM1625226	Y>C	A:389	(-11.44, -6.69, -13.49)
9:93637124	COSM1625228	M>L	A:392	(-8.81, 3.98, -12.24)
9:93639953	COSM95297	D>N	A:428	(-19.99, 8.74, -0.03)
9:93650143	COSM1723729	A>V	A:565	(-29.55, -12.26, 11.13)
9:93650155	COSM1151379	G>V	A:569	(-30.85, -17.08, 6.95)
9:93650807	COSM1701312	G>E	A:578	(-48.97, -12.26, 1.73)
9:93650818	COSM3382599	T>A	A:582	(-51.02, -8.63, 5.47)
9:93650881	COSM48799	D>H	A:603	(-37.22, -5.23, 22.30)

4FL2.A | SYK.

4FL2.A | SYK

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants