General Structure Information
| PDB ID | 3lmk |
| HGNC Gene Label(s) | GRM5 |
| Structure Name | ligand binding domain of metabotropoc glutamate receptor mglur5 complexed with glutamate |
| Resolution | 2.44Å |
| Reference | AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,D.COSSAR,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,A.BOCHKAREVTITL METABOTROPIC GLUTAMATE RECEPTOR MGLUR5 COMPLEXED WITHTITL 2 GLUTAMATEREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 438 |
| Number Of SNVs | 57 |
| Number Of Permutations | 33828 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.014 |
| p-value | 0.3 |
COSMIC
| Number Of Residues | 438 |
| Number Of SNVs | 18 |
| Number Of Permutations | 15486 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | 0.595 |
| p-value | 0.796 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 57 |
| Number Of COSMIC SNVs | 18 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.127 |
| p-value | 0.207 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
