General Structure Information
| PDB ID | 1f05 |
| HGNC Gene Label(s) | TALDO1 |
| Structure Name | crystal structure of human transaldolase |
| Resolution | 2.45Å |
| Reference | AUTH S.THORELL,P.GERGELY JR.,K.BANKI,A.PERL,G.SCHNEIDERTITL THE THREE-DIMENSIONAL STRUCTURE OF HUMANTITL 2 TRANSALDOLASE.REF FEBS LETT. V. 475 205 2000REFN ISSN 0014-5793PMID 10869557DOI 10.1016/S0014-5793(00)01658-6 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 322 |
| Number Of SNVs | 103 |
| Number Of Permutations | 18637 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.037 |
| p-value | 0.288 |
COSMIC
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 103 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.372 |
| p-value | 0.628 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 11:747528 | D>G | A:16 | (11.94, -4.00, 45.06) | |
| 11:747536 | rs138232181 | K>Q | A:19 | (7.45, -2.25, 44.47) |
| 11:747542 | rs149073638 | F>I | A:21 | (8.88, 5.57, 45.41) |
| 11:747544 | F>L | A:21 | (8.88, 5.57, 45.41) | |
| 11:747546 | rs375159325 | T>N | A:22 | (5.01, 3.13, 42.16) |
| 11:747548 | rs184467713 | T>A | A:23 | (1.73, 0.46, 42.21) |
| 11:747549 | rs144787855 | T>S | A:23 | (1.73, 0.46, 42.21) |
| 11:747552 | V>A | A:24 | (4.16, -2.51, 40.01) | |
| 11:747558 | A>V | A:26 | (1.80, -6.61, 34.77) | |
| 11:747564 | T>M | A:28 | (1.08, -9.96, 30.38) | |
| 11:755884 | D>N | A:35 | (4.95, -15.04, 40.44) | |
| 11:755886 | D>E | A:35 | (4.95, -15.04, 40.44) | |
| 11:755887 | rs561919659 COSM932039 |
E>K | A:36 | (9.54, -13.45, 38.50) |
| 11:755901 | Q>H | A:40 | (-1.27, -5.07, 43.27) | |
| 11:755918 | P>L | A:46 | (-6.14, -6.75, 22.28) | |
| 11:755938 | A>T | A:53 | (-3.50, -17.54, 22.46) | |
| 11:755944 | M>V | A:55 | (1.45, -19.01, 23.97) | |
| 11:755948 | P>L | A:56 | (1.72, -23.63, 23.54) | |
| 11:755950 | A>T | A:57 | (0.66, -23.19, 27.47) | |
| 11:755966 | V>A | A:62 | (-8.44, -21.86, 23.66) | |
| 11:755972 | rs376926927 | E>A | A:64 | (-11.73, -24.06, 28.54) |
| 11:755978 | rs146282855 | I>T | A:66 | (-13.85, -23.24, 21.67) |
| 11:755984 | rs147971604 | Y>C | A:68 | (-19.13, -20.11, 26.83) |
| 11:755989 | R>W | A:70 | (-18.26, -25.65, 20.17) | |
| 11:755990 | COSM3967839 | R>Q | A:70 | (-18.26, -25.65, 20.17) |
| 11:756001 | rs369084696 | G>R | A:74 | (-25.86, -20.22, 17.65) |
| 11:758964 | Q>R | A:79 | (-20.41, -19.99, 18.69) | |
| 11:758976 | A>V | A:83 | (-15.19, -17.44, 22.73) | |
| 11:758978 | I>V | A:84 | (-13.18, -14.02, 21.93) | |
| 11:758979 | rs200086212 | I>T | A:84 | (-13.18, -14.02, 21.93) |
| 11:758980 | I>M | A:84 | (-13.18, -14.02, 21.93) | |
| 11:758990 | F>L | A:88 | (-10.27, -11.56, 26.46) | |
| 11:759021 | K>M | A:98 | (-0.89, -16.01, 39.97) | |
| 11:759027 | COSM3416242 | P>L | A:100 | (-3.32, -9.01, 44.71) |
| 11:759033 | R>Q | A:102 | (-7.22, -3.69, 40.17) | |
| 11:759042 | T>I | A:105 | (-10.45, -6.81, 30.26) | |
| 11:759046 | E>D | A:106 | (-9.46, -3.79, 25.81) | |
| 11:759054 | A>V | A:109 | (-11.53, -1.66, 19.18) | |
| 11:759056 | R>G | A:110 | (-13.97, -4.33, 15.98) | |
| 11:760132 | D>H | A:114 | (-20.53, 2.25, 19.79) | |
| 11:760139 | rs200597243 | D>V | A:116 | (-24.49, 2.38, 23.75) |
| 11:760142 | COSM4036780 | A>V | A:117 | (-21.44, -1.10, 22.71) |
| 11:760145 | rs374070075 | M>T | A:118 | (-18.11, 0.51, 24.59) |
| 11:760162 | R>W | A:124 | (-21.55, -10.81, 28.49) | |
| 11:760163 | rs149702835 | R>Q | A:124 | (-21.55, -10.81, 28.49) |
| 11:760169 | I>T | A:126 | (-18.55, -7.76, 34.66) | |
| 11:760190 | G>E | A:133 | (-16.59, -15.80, 40.89) | |
| 11:760214 | I>T | A:141 | (-13.40, -2.67, 31.62) | |
| 11:760226 | S>L | A:145 | (-9.55, 7.26, 25.03) | |
| 11:760252 | K>E | A:154 | (-19.53, 9.18, 33.05) | |
| 11:763345 | E>K | A:155 | (-22.87, 4.94, 31.38) | |
| 11:763351 | rs140952110 | E>K | A:157 | (-17.56, 4.14, 36.93) |
| 11:763355 | E>V | A:158 | (-21.88, 7.57, 37.08) | |
| 11:763357 | rs144914498 | Q>E | A:159 | (-25.40, 4.65, 35.94) |
| 11:763358 | rs147961544 | Q>R | A:159 | (-25.40, 4.65, 35.94) |
| 11:763368 | I>M | A:162 | (-18.48, -1.14, 35.92) | |
| 11:763376 | N>S | A:165 | (-8.29, 1.11, 31.95) | |
| 11:763382 | T>M | A:167 | (-6.49, 3.03, 26.85) | |
| 11:763387 | L>F | A:169 | (-4.40, 8.68, 27.15) | |
| 11:763388 | rs142801207 | L>P | A:169 | (-4.40, 8.68, 27.15) |
| 11:763397 | F>S | A:172 | (-3.95, 17.75, 28.95) | |
| 11:763399 | A>T | A:173 | (-7.65, 16.29, 26.39) | |
| 11:763420 | E>K | A:180 | (-14.11, 16.35, 33.75) | |
| 11:763424 | rs201855399 | A>V | A:181 | (-15.49, 11.30, 33.99) |
| 11:763432 | T>A | A:184 | (-10.96, 4.29, 38.14) | |
| 11:763433 | T>I | A:184 | (-10.96, 4.29, 38.14) | |
| 11:763447 | F>L | A:189 | (0.06, 4.17, 25.73) | |
| 11:763456 | R>C | A:192 | (2.38, 3.40, 21.18) | |
| 11:763457 | rs151052416 | R>H | A:192 | (2.38, 3.40, 21.18) |
| 11:763486 | rs140985565 | D>N | A:202 | (14.96, 15.99, 13.98) |
| 11:763499 | Y>C | A:206 | (13.83, 12.61, 23.44) | |
| 11:763501 | E>K | A:207 | (17.87, 12.73, 28.53) | |
| 11:763756 | S>T | A:216 | (2.73, 13.56, 28.82) | |
| 11:763758 | rs1804555 | V>I | A:217 | (2.62, 11.13, 32.29) |
| 11:763769 | I>M | A:220 | (-1.42, 13.94, 33.01) | |
| 11:763784 | K>N | A:225 | (-2.57, 14.42, 42.08) | |
| 11:763792 | S>N | A:228 | (-8.11, 16.61, 43.75) | |
| 11:763795 | Y>C | A:229 | (-9.51, 15.53, 39.27) | |
| 11:763801 | T>S | A:231 | (-8.19, 9.25, 38.35) | |
| 11:763806 | V>I | A:233 | (-2.02, 7.98, 36.93) | |
| 11:763811 | M>I | A:234 | (-1.40, 3.15, 34.76) | |
| 11:763815 | rs375231328 COSM247705 |
A>T | A:236 | (2.05, 2.71, 29.65) |
| 11:763829 | N>K | A:240 | (13.11, 2.77, 28.26) | |
| 11:763839 | I>F | A:244 | (10.06, 3.28, 34.15) | |
| 11:763852 | A>D | A:248 | (8.97, 7.64, 39.89) | |
| 11:763854 | G>S | A:249 | (5.59, 8.23, 41.77) | |
| 11:763872 | I>F | A:255 | (6.14, -2.74, 33.53) | |
| 11:763891 | G>E | A:261 | (13.77, -7.76, 34.70) | |
| 11:763911 | rs138088112 | A>T | A:268 | (20.53, 1.81, 41.24) |
| 11:763912 | rs149446418 | A>D | A:268 | (20.53, 1.81, 41.24) |
| 11:763914 | rs143020914 | K>E | A:269 | (19.21, 5.32, 44.63) |
| 11:763916 | K>N | A:269 | (19.21, 5.32, 44.63) | |
| 11:763920 | V>M | A:271 | (15.08, 9.29, 42.79) | |
| 11:763923 | P>S | A:272 | (11.68, 9.93, 43.94) | |
| 11:763926 | V>L | A:273 | (10.23, 12.28, 40.04) | |
| 11:763939 | K>T | A:277 | (4.33, 17.79, 48.09) | |
| 11:764296 | S>G | A:282 | (2.46, 23.08, 39.11) | |
| 11:764300 | D>G | A:283 | (2.06, 26.25, 35.89) | |
| 11:764305 | E>Q | A:285 | (-4.51, 27.27, 34.74) | |
| 11:764314 | H>Y | A:288 | (-15.27, 22.14, 31.29) | |
| 11:764323 | rs567606097 | E>K | A:291 | (-18.07, 16.72, 22.28) |
| 11:764345 | H>P | A:298 | (-7.31, 15.23, 20.49) | |
| 11:764350 | rs1804554 | E>K | A:300 | (-4.33, 21.68, 18.24) |
| 11:764368 | E>K | A:306 | (-1.38, 10.69, 13.99) | |
| 11:764371 | K>Q | A:307 | (-0.13, 7.03, 17.82) | |
| 11:764374 | rs188547252 | L>V | A:308 | (-6.17, 7.38, 19.27) |
| 11:764383 | G>R | A:311 | (-4.46, 2.05, 17.86) | |
| 11:764384 | rs140887745 | G>E | A:311 | (-4.46, 2.05, 17.86) |
| 11:764389 | R>S | A:313 | (-5.98, 1.86, 12.51) | |
| 11:764392 | K>E | A:314 | (-2.34, -1.49, 15.33) | |
| 11:764401 | rs139416578 | A>T | A:317 | (-6.46, -6.20, 13.90) |
| 11:764414 | rs11302 | K>R | A:321 | (-4.87, -12.44, 13.72) |
| 11:764422 | rs200473365 | R>W | A:324 | (-8.63, -14.65, 10.61) |
| 11:764423 | rs186015859 | R>Q | A:324 | (-8.63, -14.65, 10.61) |
| 11:764813 | rs369679261 | E>K | A:328 | (-10.28, -21.44, 10.34) |
| 11:764819 | M>L | A:330 | (-14.82, -23.19, 16.14) | |
| 11:764822 | F>V | A:331 | (-16.82, -23.10, 12.88) | |
| 11:764826 | N>S | A:332 | (-12.91, -26.55, 10.27) |
[+] COSMIC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 11:755975 | COSM690647 | A>E | A:65 | (-13.55, -20.97, 25.00) |
| 11:759053 | COSM178058 | A>T | A:109 | (-11.53, -1.66, 19.18) |
| 11:763815 | COSM247705 | A>T | A:236 | (2.05, 2.71, 29.65) |