General Structure Information
| PDB ID | 3rbn |
| HGNC Gene Label(s) | MLH1 |
| Structure Name | crystal structure of mutl protein homolog 1 isoform 1 [homo sapiens] |
| Resolution | 2.16Å |
| Reference | AUTH L.DOMBROVSKY,A.DONG,A.WERNIMONT,P.LOPPNAU,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,H.WUTITL CRYSTAL STRUCTURE OF MUTL PROTEIN HOMOLOG 1 ISOFORM 1 [HOMOTITL 2 SAPIENS]REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 234 |
| Number Of SNVs | 67 |
| Number Of Permutations | 38489 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.078 |
| p-value | 0.213 |
ClinVar
| Number Of Residues | 234 |
| Number Of SNVs | 21 |
| Number Of Permutations | 11690 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.443 |
| p-value | 0.005 |
COSMIC
| Number Of Residues | 234 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.167 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 67 |
| Number Of ClinVar SNVs | 19 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.205 |
| p-value | 0.008 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 67 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | -0.275 |
| p-value | 0.743 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
