General Structure Information
| PDB ID | 3qs9 |
| HGNC Gene Label(s) | FLT3 |
| Structure Name | crystal structure of a human flt3 ligand-receptor ternary complex |
| Resolution | 7.8Å |
| Reference | AUTH K.VERSTRAETE,G.VANDRIESSCHE,M.JANUAR,J.ELEGHEERT,AUTH 2 A.V.SHKUMATOV,A.DESFOSSES,K.VAN CRAENENBROECK,D.I.SVERGUN,AUTH 3 I.GUTSCHE,B.VERGAUWEN,S.N.SAVVIDESTITL STRUCTURAL INSIGHTS INTO THE EXTRACELLULAR ASSEMBLY OF THETITL 2 HEMATOPOIETIC FLT3 SIGNALING COMPLEX.REF BLOOD V. 118 60 2011REFN ISSN 0006-4971PMID 21389326DOI 10.1182/BLOOD-2011-01-329532 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 405 |
| Number Of SNVs | 101 |
| Number Of Permutations | 41769 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.022 |
| p-value | 0.752 |
COSMIC
| Number Of Residues | 405 |
| Number Of SNVs | 11 |
| Number Of Permutations | 5783 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.145 |
| p-value | 0.897 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 101 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 53.0 |
| K Statistic | 0.178 |
| p-value | 0.808 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
