General Structure Information
| PDB ID | 3hmn |
| HGNC Gene Label(s) | TTK |
| Structure Name | crystal structure of human mps1 catalytic domain in complex with atp |
| Resolution | 2.7Å |
| Reference | AUTH M.L.CHU,Z.LANG,L.M.CHAVAS,J.NERES,O.S.FEDOROVA,L.TABERNERO,AUTH 2 M.CHERRY,D.H.WILLIAMS,K.T.DOUGLAS,P.A.EYERSTITL BIOPHYSICAL AND X-RAY CRYSTALLOGRAPHIC ANALYSIS OF MPS1TITL 2 KINASE INHIBITOR COMPLEXES.REF BIOCHEMISTRY V. 49 1689 2010REFN ISSN 0006-2960PMID 20099905DOI 10.1021/BI901970C |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 255 |
| Number Of SNVs | 60 |
| Number Of Permutations | 10259 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.038 |
| p-value | 0.946 |
COSMIC
| Number Of Residues | 255 |
| Number Of SNVs | 4 |
| Number Of Permutations | 111 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.333 |
| p-value | 0.314 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 60 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.359 |
| p-value | 0.456 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
