General Structure Information
| PDB ID | 3o96 |
| HGNC Gene Label(s) | AKT1 |
| Structure Name | crystal structure of human akt1 with an allosteric inhibitor |
| Resolution | 2.7Å |
| Reference | AUTH W.I.WU,W.C.VOEGTLI,H.L.STURGIS,F.P.DIZON,G.P.VIGERS,AUTH 2 B.J.BRANDHUBERTITL CRYSTAL STRUCTURE OF HUMAN AKT1 WITH AN ALLOSTERIC INHIBITORTITL 2 REVEALS A NEW MODE OF KINASE INHIBITION.REF PLOS ONE V. 5 12913 2010REFN ESSN 1932-6203PMID 20886116DOI 10.1371/JOURNAL.PONE.0012913 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 367 |
| Number Of SNVs | 60 |
| Number Of Permutations | 9072 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.21 |
| p-value | 0.07 |
COSMIC
| Number Of Residues | 367 |
| Number Of SNVs | 7 |
| Number Of Permutations | 1842 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.476 |
| p-value | 0.082 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 60 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.332 |
| p-value | 0.012 |